ABSTRACT
The article deals with problems of performing detoxication in complex treatment of acute ileus. A method of plasmapheresis is proposed for treatment of patients with a pronounced intoxication syndrome. Criteria for the estimation of the patient's state are presented which are considered as indications for extracorporal detoxication and for effectiveness of plasmapheresis both by clinical criteria of the estimation of the patient's state and by laboratory findings. High efficiency of the method is shown in complex treatment of patients with acute ileus with a pronounced intoxication syndrome.
Subject(s)
Intestinal Obstruction/surgery , Plasmapheresis , Toxemia/therapy , Acute Disease , Adult , Aged , Female , Humans , Intestinal Obstruction/complications , Male , Middle Aged , Postoperative Care , Toxemia/etiologyABSTRACT
Experiments were conducted on 75 rabbits to study the efficacy of endolymphatic administration of aceclidine, obsidan, and cerucal for stimulation of the intestine in its experimental paresis. The stimulating effect of the pharmacological agents was found to be of a longer duration in endolymphatic that in intravenous administration. This allowed endolymphatic pharmacological stimulation of the intestine to be suggested for the use in abdominal surgery.
Subject(s)
Abdomen/surgery , Gastrointestinal Motility/drug effects , Intraoperative Care/methods , Metoclopramide/administration & dosage , Propranolol/administration & dosage , Quinuclidines/administration & dosage , Animals , Drug Evaluation, Preclinical , Emergencies , Female , Injections, Intralymphatic , Injections, Intravenous , Male , Rabbits , Stimulation, ChemicalABSTRACT
An experience with the treatment of 199 patients with different forms of peritonitis enabled the authors to recommend to include the moving-blood ultraviolet irradiation in the complex therapy followed by hemosorption. It reduced lethality two times.
Subject(s)
Blood/radiation effects , Hemoperfusion , Peritonitis/surgery , Ultraviolet Therapy , Adolescent , Adult , Aged , Combined Modality Therapy , Female , Humans , Male , Middle Aged , Postoperative CareABSTRACT
The article discusses the results of complex surgical treatment of 108 patients with acute intestinal obstruction which was caused by benign lesions in 64 and by malignant tumors of the rectum in 44 patients. Twenty-three persons (21.2%) died after palliative and radical operations. The main causes of death were intoxication (52.2% of fatal cases) and peritonitis (26.1%). Hemosorption is the most effective measure for the prevention and treatment of the endogenous intoxication syndrome in the postoperative period. A brief therapeutic effect or inefficacy of hemosorption is evidence of persistence of the pathological process in the abdominal cavity.
Subject(s)
Intestinal Obstruction/therapy , Acute Disease , Adult , Aged , Aged, 80 and over , Combined Modality Therapy , Female , Humans , Male , Middle AgedSubject(s)
Complement System Proteins/analysis , Myocardial Infarction/immunology , Animals , Complement C3/deficiency , Dogs , Female , Male , Time FactorsSubject(s)
Carbon , Hemoperfusion , Anemia, Hemolytic/therapy , Animals , Child, Preschool , Dogs , Humans , Infant , Infant, Newborn , Insulin/blood , Shock, Septic/therapy , Vitamin B 12/bloodABSTRACT
Procedures for removal of 5-fluorouracil from biological fluids by means of ADB-13 ty uncoated activated carbon were studied in vivo and in vitro. Dynamic stand trials showed a high sorptive capacity of carbon which appeared to depend on the rate and duration of perfusion. A 40 min passage through a carbon column at the perfusion rate of 100 ml/min was followed by a 584-fold decrease of the drug concentration. The pharmacodynamics of 5-fluorouracil was studied in dogs. The agent was injected intraperitoneally. The maximal hemosorptive effect was registered after the injection of lethal doses of 100 mg/kg. When therapeutic doses of 30 mg/kg were given hemosorption resulted in increased blood levels of the freely circulating drug.
Subject(s)
Fluorouracil/blood , Hemoperfusion , Animals , Dogs , Dose-Response Relationship, Drug , Fluorouracil/administration & dosage , KineticsABSTRACT
The article presents results of the treatment of children with pyo-septic diseases by method of hemosorption and lymphosorption. The experience with 86 hemosorptions and 3 lymphosorptions in 33 patients is generalized. Analysis of results of the treatment of pyo-septic conditions by extracorporal method of detoxication enabled the correlation of the effect with the course of the disease, age of the patient and the pathogenic agent of the purulent process to be detected.
