ABSTRACT
An increase in frequency of heart contractions, changes in the bioelectrical heart activity and decrease of the force-pump heart function are observed in the rabbits with model chronic ischemic heart disease lipid metabolism in significantly changed the concentration of cholesterol in the right ventricle myocardium as well as the concentrations of unsaturated lipid acids in the heart tissues increase, while the content of saturated lipid acids and antioxidant activity of plasma decrease. Bioenergetic processes change as follows: succinate-dehydrogenase and alpha-keto-glutarate-dehydrogenase activity decrease, while the concentrations of glycogen, lactic and pyruvic acids and lactate dehydrogenase activity in the heart tissues increase.
Subject(s)
Cholesterol, Dietary/administration & dosage , Myocardial Ischemia/metabolism , Animals , Cholesterol/metabolism , Chronic Disease , Disease Models, Animal , Glycogen/metabolism , Ketoglutarate Dehydrogenase Complex/metabolism , L-Lactate Dehydrogenase/metabolism , Lactates/metabolism , Lactic Acid , Lipid Metabolism , Myocardial Contraction/physiology , Myocardial Ischemia/chemically induced , Oxidation-Reduction , Pyruvates/metabolism , Pyruvic Acid , Rabbits , Succinate Dehydrogenase/metabolismABSTRACT
While laboratory experimental model of coronary heart disease (according to Frol'kis et al.) is developed, activity of succinate dehydrogenase, alpha-ketoglutarate dehydrogenase, Na+, Ka(+)- and Mg2+ ATPase decreases, but activity of lactate dehydrogenase and concentrations of lactic and pyruvic acids in the heart tissue increase. At the same time concentration of glycogene increases more than twice. As far as we can see there is an evidence of a decrease of glycogene utilization due to change in levels of regulatory processes. Despite a decrease of ATP synthesis by the inhibition of tricarboxylic acid cycle the ATP:ADP relation reduces to ATP, as emphatic inhibition of ATPase in the heart tissues takes place in development of the model of the coronary heart disease. The relation between ATP and ADP is considered as a regulator of glycogene utilization. In the liver tissue activity of succinate dehydrogenase, alpha-ketoglutarate dehydrogenase, Na+, K(+)- and Mg2+ ATPase falls, while concentrations of lactic acid grow. No accumulation of glycogen is observed. It is obvious that there are controversial metabolic processes. Experimental data are discussed.
Subject(s)
Glycogen/metabolism , Liver Glycogen/metabolism , Liver/metabolism , Myocardial Ischemia/metabolism , Myocardium/metabolism , Animals , Chronic Disease , Disease Models, Animal , Energy Metabolism , Glycogen/analysis , Liver/chemistry , Liver Glycogen/analysis , Myocardium/chemistry , Oxidation-Reduction , RabbitsABSTRACT
The irritating, sensitizing, and toxic effect of water produced by the method of carbon dioxide hydration was examined in animal experiments and human observations. It was found that before and after decontamination this water did not cause skin irritation or organism sensitization, did not have a toxic effect on the CNS, liver, kidneys or blood morphology, and did not deteriorate adaptive capabilities of the animal or human body.
Subject(s)
Aerospace Medicine , Carbon Dioxide/chemical synthesis , Ecological Systems, Closed , Hydrogen Bonding , Nickel/toxicity , Space Flight , Water Pollutants, Chemical/toxicity , Water Supply/standards , Animals , Guinea Pigs , Humans , Nickel/isolation & purification , Rats , USSR , Water Pollutants, Chemical/isolation & purification , Water Supply/analysisABSTRACT
Influence of electrolysis gaseous oxygen (EGO) mixed with nitrogen (1:4) on the living organism was studied in a 30-day 24-hour experiment on guinea pigs. A preliminary conclusion states, that EGO, obtained in the system with a solid polymeric electrolyte out of moist materials of different chemical composition, can be recommended for the formation of artificial gas atmosphere in hermetic objects in the mixture with gaseous nitrogen in the ratio 1:4.
Subject(s)
Electrolysis/methods , Health Status , Models, Biological , Nitrogen/chemistry , Oxygen/toxicity , Water/chemistry , Animals , Guinea Pigs , Oxygen/chemistry , Oxygen/isolation & purification , Time FactorsABSTRACT
The authors evaluated the problems of hygienic aspects of oxygen obtained by the method of electrolytic decomposition of water with a different content of chemical substances in the system with a hard polymere electrolyte. On the basis of sanitary-chemical qualities and toxicological properties electrolysis gaseous oxygen may be recommended for use in creating an artificial gaseous atmosphere in hermetically sealed compartments in mixture with gaseous nitrogen (ratio 1:4).
Subject(s)
Electrolysis , Oxygen/toxicity , Polymers/toxicity , Animals , Environment, Controlled , Male , Nitrogen/toxicity , Oxygen/isolation & purification , Rats , Time FactorsABSTRACT
It has been shown that gaseous oxygen produced in a system containing a solid polymer electrolyte from distilled water and two water samples containing different concentrations of chemicals meets on the whole USSR Standard 5583-78 and iso standard 2046. This oxygen underwent toxic evaluations on 60 white noninbred male rats. When mixed with gaseous nitrogen (1:4), electrolytically produced oxygen exerted no unfavorable effects on the animals.
