ABSTRACT
The paper discusses the concept of risk-group patients who have an increased probability of immediate systemic adverse reactions to contrast agents used clinically in various radiodiagnostic techniques. It analyzes the pathogenesis of allergoid reactions to X-ray and magnetic resonance, contrast media. On this basis, the authors describe the abnormalities and nosological entities the patients had in their medical history before diagnostic studies will be indicative of the increased risk of these complications to the administration of a contrast agent.
Subject(s)
Contrast Media/adverse effects , Disease/etiology , Gadolinium/adverse effects , Iodine Radioisotopes/adverse effects , Radiopharmaceuticals/adverse effects , Gadolinium/administration & dosage , Humans , Iodine Radioisotopes/administration & dosage , Magnetic Resonance Imaging/adverse effects , Radiopharmaceuticals/administration & dosage , Risk FactorsSubject(s)
Angioplasty, Balloon, Coronary/adverse effects , Coronary Restenosis , Drug-Eluting Stents/adverse effects , Myocardial Ischemia/diagnosis , Myocardial Ischemia/therapy , Angioplasty, Balloon, Coronary/methods , Coronary Restenosis/etiology , Coronary Restenosis/pathology , Coronary Restenosis/physiopathology , Coronary Vessels/pathology , Coronary Vessels/physiopathology , Humans , Inflammation/pathology , Inflammation/physiopathology , Myocardial Ischemia/physiopathology , Platelet Aggregation , Prognosis , Risk Factors , Time , Tunica Intima/injuries , Tunica Intima/pathology , Tunica Intima/physiopathologyABSTRACT
The study was undertaken to assess the long-term results of recanalization of chronically occluded coronary arteries, by applying drug-eluting stents to patients with coronary heart disease. The study enrolled 585 patients with one-vessel occlusive lesion of one of three great coronary arteries (TIMI 0; occlusion duration, > or = 3 months): 321 patients who underwent successful recanalization of chronic occlusion and further implantation of drug-eluting stents and 264 patients who received drug therapy (a control group). The short- and long-term results of recanalization were investigated. The follow-up averaged 1095 +/- 36 days; reexaminations were made after 1, 2, and 3 years. The direct success rate of recanalization of chronically occluded coronary arteries was 84.9% (321/378). The results of a 3-year follow-up showed the efficiency and expediency of endovascular recanalization of chronic occlusions: the invasively treated patients had the symptoms of angina pectoris and heart failure significantly less frequently, showed higher exercise tolerance and a less need for antianginal therapy, and had a better long-term prognosis.
