ABSTRACT
Electrokymography was used to assess by pulmonary densograms and pulmonary artery pulse curves treatment-induced changes in cardiac contractility and lesser circulation in 455 patients with rheumatic heart disease and stage IIA, IIB, and III circulatory insufficiency. Treatment with cardiac glycosides in combination with metabolic preparations (ATP methionine, vitamin B12, inosine-F, and extract of the heart muscle) leads to a more conspicuous reduction in the symptoms of congestion in the lesser circulation than that encountered in treatment with cardiac glycosides alone. The reduction in these symptoms following treatment with ATP and heart-muscle extract may be explained not only by improved myocardial contractility but also by the direct vasodilating effect of adenyl compounds.
Subject(s)
Cardiac Glycosides/therapeutic use , Pulmonary Circulation/drug effects , Rheumatic Heart Disease/drug therapy , Adenosine Triphosphate/therapeutic use , Drug Therapy, Combination , Electrokymography , Follow-Up Studies , Humans , Inosine/therapeutic use , Methionine/therapeutic use , Vitamin B 12/therapeutic useABSTRACT
Analysis of the dynamics of changes in the end part of the ECG ventricular complex in 311 patients with rheumatic heart disease and stages IIA, IIB, and III circulatory insufficiency after treatment with preparations of digitalis and their combination with biologically active substances (orotic acid, vitamin B12, calcium pantothenate, ATP, methionine, inosi-F) is presented. When digitalis glycosides are used with preparations that have an effect on the nucleic acid synthesis and energy production, the "digitalis--induced" changes in the end part of the ECG ventricular complex are less marked while the clinical effect of treatment is more appreciable
