ABSTRACT
A whole-transcriptome analysis of gene expression in six samples of clear cell renal cancer was performed. Using bioinformatics methods, we established a relationship between gene expression data and changes in activity of metabolic pathways: in this cancer type, the expression of genes involved in the metabolism of carbohydrates, lipids, and amino acids as well as in energy metabolism changed most significantly.
Subject(s)
Carcinoma, Renal Cell/genetics , Carcinoma, Renal Cell/metabolism , Gene Expression Regulation, Neoplastic , Kidney Neoplasms/genetics , Kidney Neoplasms/metabolism , Metabolic Networks and Pathways/genetics , Aged , Female , Humans , Male , Middle AgedABSTRACT
The theory of large radius polaron in the quantum wire is developed. The interaction of charge particles with interface optical phonons as well as with optical phonons localized in the quantum wire is taken into account. The interface phonon contribution is shown to be dominant for narrow quantum wires. The wave functions and polaron binding energy are found. It is determined that polaron binding energy depends on the electron mass inside the wire and on the polarization properties of the barrier material.
