[Characteristics of the clinical picture and of neuromediator metabolism in reactive depression]. / Osobennosti kliniki i neiromediatornogo obmena pri reaktivnoi depressii.

The so-called "pure" depressive states in the structure of psychogenic diseases occur less frequently nowadays. Therefore, the pathomorphosis of mental disorders which has been observed recently in clinical manifestations of different mental diseases complicates the differential diagnosis. To obviate this difficulty one of the most important diagnostic methods, namely measurement of the blood levels of neuromediators (noradrenaline, acetylcholine) in patients with reactive depression was used to study the neuromediator metabolism which is most closely related to changes in the emotional sphere. This is of great significance for the understanding of mechanisms of the formation of the clinical pattern of various depressive states and approaches to the disease diagnosis. These characteristics may be of use in selecting the mode of therapy.

[Neuromediator shifts in the peripheral blood of dogs resulting from negative emotiogenic exposure]. / Neiromediatornye sdvigi v perifericheskoi krovi sobak vsledstvie otritsatel'nogo émotsiogennogo vozdeistviia.

The analysis of negative emotiogenic influence in dogs carried out according to dynamics of levels of acetylcholine and catecholamine content in peripheral blood and concomitant changes of the higher nervous activity, allows to conclude about the participation of both cholinergic and catecholaminergic neurotransmitter systems in reactions to this influence with a relative predominance of the first one. In animals with decreased reactivity and with compensatory abilities of the cholinergic system, the same influence leads to enhancement of the specific significance of the reaction of the catecholaminergic system, and especially of its transmitter, noradrenergic component.

[Clinical and experimental studies of the role of neuromediator systems in the pathogenesis of neurosis and neurosis-like states]. / Klinicheskie i éksperimental'nye issledovaniia roli neiromediatornykh sistem v patogeneze nevrozov i nevrozopodobnykh sostoianii.

Clinical studies revealed a significant increase in the peripheral blood levels of noradrenaline in patients with different forms of neurosis and neurosis-like states as compared to control subjects as well as heterogeneous or unidirectional but differently pronounced changes in blood levels of acetylcholine and adrenaline. Comparison of the clinical findings with the results of dynamic assays for peripheral levels of acetylcholine and catecholamine in dogs exposed to special psychogenic and physiogenic impacts has helped to form an understanding about some common mechanisms of the formation of neuroses and neurosis-like states. The authors emphasize the consistency of neuromediator shifts in the blood of patients and the possibility of using this parameter for the differential diagnosis of various forms of neurotic disturbances at the initial stage of the disease.

[Effect of hemosorption on changes in the concentration of neuromediators among dermatosis patients with borderline neuropsychological disorders]. / Vliianie gemosorbtsii na izmenenie soderzhaniia neiromediatorov u bol'nykh dermatozami s pogranichnymi nervno-psikhicheskimi rasstroistvami.

The levels of catecholamines and acetylcholine were studied in the peripheral blood of 56 patients with psoriasis and neurodermitis and attendant borderline neuropsychic disorders. Hemosorption was carried out in all patients, some of them recieving psychotropic therapy prior to it. The analysis of the results showed a difference in the content of the neurotransmitters in the blood of patients with different neuropsychic disorders and also in patients with and without the psychotropic therapy. Hemosorption intensified the reaction of the neurotransmitter systems and may be considered as a physiological and psychological stressor. Following the psychocorrective therapy there was a more adequate reaction of the neurotransmitters to hemosorption and a more marked (versus control) improvement in the dermatological and psychic status of the patients.

[Effect of long-term exposure to a high-intensity permanent magnetic field on the activity of body adrenergic and cholinergic systems]. / Vliianie dlitel'nogo vozdeistviia postoiannogo magnitnogo polia vysokoi napriazhennosti na aktivnost' adrenergicheskikh i kholinergicheskikh sistem organizma.

The mice exposed for 1 month to a constant magnetic field of 1.6 T showed a significant increase in the epinephrine and norepinephrine concentration of blood. The acetylcholine content of blood grew on the 3rd week of the exposure. The content of neurotransmitters in the brain tissue increased during the 3rd week and returned to the normal by the end of the exposure.

[Exposure to permanent magnetic fields and the reticular effects on the adrenergic and cholinergic systems]. / Vozdeistvie postoiannykh magnitnykh polei i retikuliarnye vliianiia na adrenergicheskie i kholinergicheskie sistemy.

An exposure of rats to a constant magnetic field of 0.4 T for 1 hour caused increases in the blood content of adrenaline, noradrenaline, and acetylcholine, and in the adrenal content of adrenaline. Stimulation of the midbrain reticular formation led to a significant increase of the blood concentration of catecholamines and acetylcholine. After an exposure to the constant magnetic field the stimulatory effects of the reticular formation on the adrenergic systems diminished and on the cholinergic systems remained elevated.

[Clinicobiochemical parallels in borderline neuropsychic disorders]. / Kliniko-biokhimicheskie paralleli pri pogranichnykh nervno-psikhicheskikh rasstroistvakh.

Under examination there were 173 patients with borderline neuropsychic disorders of the neurotic and neurosis-like genesis. In the course of the treatment the levels of acetylcholine and catecholamines were determined. It has been shown that in borderline neuropsychic disorders there are statistically significant differences in the levels of those neuromediators, these differences being characteristic for the neurotic and neurosis-like disorders. The process of the normalization of those levels was found to depend on the initial changes, which, in their turn, depended on the etiopathogenesis of the borderline disorders.

[Clinical picture and activity of nervous system mediators during chronic modeling of certain factors involved in space flight]. / Klinika i aktivnost' mediatorov nervnoi sistemy pri dlitel'nom modelirovanii nekotorykh faktorov kosmicheskogo poleta.

Results of examining the functions of the nervous system and the activity of blood neuromediators after a long-time (182 days) antiorthostatic hypokinesia are presented. It has been shown that along with polymorphic clinical signs on the part of the nervous system (hemodynamic disturbances, asthenoneurotic manifestations, neuromuscular, metabolic, trophic, and vegetovascular disturbances, signs of insufficient training of the cardiovascular system, stato-kinetic and pain phenomena) undulating changes of the neuromediator activity reflecting the course of compensation and adaptation processes in the conditions of long-time hypokinesia are observed.

[State of neuromediator systems during formation of the psychoorganic syndrome caused by hypertension]. / Sostoianie neiromediatornykh sistem pri formirovanii psikhoorganicheskogo sindroma, obuslovlennogo gipertonicheskoi bolezn'iu.

The state of the neuromediator systems in the formation of a psychosomatic development was studied in 66 patients with different stages of the hypertensive disease. It was demonstrated that the phases of the psychoorganic syndrome frequently correlated with the stages of hypertensive disease and with the qualitative and quantitative transformation of neuromediators in the peripheral blood and that the reactions of the neuromediator systems to dosaged stress may be used to evaluate the stage of the psychoorganic syndrome.