ABSTRACT
The effects of menopause and renal function on serum parameters of the vitamin D-endocrine system were studied in a cross-sectional sample of 676 healthy women aged 20-74 years in Shiraz. Low serum 25-hydroxyvitamin D (25-OHD) was found in 52.9% of the women. Serum parathyroid hormone (PTH) increased significantly over the age span in premenopausal women (r= 0.13, P= 0.02). In premenopausal and postmenopausal women, serum levels of 25-OHD, phosphorus and calcium were stable across the age span. There was no significant correlation between creatinine clearance or serum PTH (r= -0.016, P= 0.66) and 25-OHD (r= 0.012, P= 0.74). The high prevalence of vitamin D deficiency warrants consideration of dietary supplementation.
Subject(s)
Kidney/physiology , Menopause/physiology , Vitamin D Deficiency/blood , Vitamin D/analogs & derivatives , Adult , Aged , Aging/physiology , Alkaline Phosphatase/blood , Calcium/blood , Creatinine/blood , Cross-Sectional Studies , Female , Health Surveys , Humans , Iran/epidemiology , Middle Aged , Parathyroid Hormone/blood , Phosphorus/blood , Postmenopause/physiology , Premenopause/physiology , Prevalence , Sampling Studies , Urban Health/statistics & numerical data , Vitamin D/blood , Vitamin D Deficiency/epidemiology , Vitamin D Deficiency/etiologyABSTRACT
The effects of menopause and renal function on serum parameters of the vitamin D-endocrine system were studied in a cross-sectional sample of 676 healthy women aged 20-74 years in Shiraz. Low serum 25-hydroxyvitamin D [25-OHD] was found in 52.9% of the women. Serum parathyroid hormone [PTH] increased significantly over the age span in premenopausal women [r= 0.13, P= 0.02]. In premenopausal and postmenopausal women, serum levels of 25-OHD, phosphorus and calcium were stable across the age span. There was no significant correlation between creatinine clearance or serum PTH [r= -0.016, P= 0.66] and 25-OHD [r= 0.012, P= 0.74]. The high prevalence of vitamin D deficiency warrants consideration of dietary supplementation
