Subject(s)
Antibodies, Antiphospholipid/blood , Connective Tissue Diseases/complications , Dermis , Elastic Tissue , Lupus Erythematosus, Systemic/blood , Lupus Erythematosus, Systemic/complications , Adult , Connective Tissue Diseases/pathology , Dermis/pathology , Elastic Tissue/pathology , Humans , Male , Skin/pathologyABSTRACT
INTRODUCTION AND CLINICAL CASE: We report a new unusual case of a patient without known familiar history of melanocytic schwannoma or Carney complex with multiple melanocytic schwannoma in the spinal canal. Histologically, the tumor was composed of irregular interlacing spindle-shaped cells with pigments. The diagnosis is made by immunohistochemical techniques and electron microscopy findings. CONCLUSION: We review the literature, and the different theories on the origin of these tumors are discussed.
Subject(s)
Melanocytes/pathology , Neurilemmoma/pathology , Spinal Cord Neoplasms/pathology , Adult , Cell Movement/physiology , Humans , Immunohistochemistry , Magnetic Resonance Imaging , Male , Neurilemmoma/metabolism , Protein S/metabolism , Spinal Cord Neoplasms/metabolismABSTRACT
Introducción y caso clínico. Presentamos un nuevo y poco frecuente caso de un paciente sin historia familiar conocida de schwannoma melanocítico o de complejo de Carney, con múltiples schwannomas melanocíticos del canal raquídeo. El estudio histológico reveló que el tumor se componía de células fusiformes irregulares y pigmentadas entrelazadas. El diagnóstico se llevó a cabo por medio de técnicas inmunohistoquímicas y de acuerdo con los hallazgos de microscopía electrónica. Conclusión. Revisamos la literatura y las diferentes teorías acerca del origen de estos tumores (AU)
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Subject(s)
Adult , Male , Humans , Protein S , Melanocytes , Neurilemmoma , Cell Movement , Magnetic Resonance Imaging , Immunohistochemistry , Spinal Cord NeoplasmsABSTRACT
Sinus histiocytosis with massive lymphadenopathy is an entity that exceptionally appears as a purely cutaneous disease. We described 2 cases of this form with spontaneous involution. Histology showed a polymorphic infiltrate in the dermis and hypodermis composed of large histiocytes with lymphophagocytosis, neutrophils and plasma cells. Immunohistochemical stains demonstrated the positivity of histiocytes for protein S-100 and MAC 387.
