ABSTRACT
A binuclear Cu(II) cofactor was covalently bound to a lauric acid anchor. The resulting conjugate was characterized then combined with beta-lactoglobulin (ßLG) to generate a new biohybrid following the so-called "Trojan horse" strategy. This biohybrid was examined for its effectiveness in the oxidation of a catechol derivative to the corresponding quinone. The resulting biohybrid did not exhibit the sought after catecholase activity, likely due to its ability to bind and stabilize the semiquinone radical intermediate DTB-SQ. This semi-quinone radical was stabilized only in the presence of the protein and was characterized using optical and magnetic spectroscopic techniques, demonstrating stability for over 16â hours. Molecular docking studies revealed that this stabilization could occur owing to interactions of the semi-quinone with hydrophobic amino acid residues of ßLG.
Subject(s)
Aspergillosis/complications , Burns/complications , Wound Infection/microbiology , Female , Humans , Middle AgedABSTRACT
For a decade, depth of anesthesia monitoring has become a reality in the operating room. It provides valuable help for managing anesthesia, especially for unstable patients. This might be particularly relevant during aeromedical evacuation. In this study, we aimed to assess the validity of the bispectral index (BIS) during long-range patient transportation aboard fixed-wing aircraft. BIS was recorded in 30 patients, 25 under anesthesia and 5 awake, during aeromedical evacuations performed by the French Air Force. BIS index was available and analyzable (signal quality index above 50%) more than 90% of time. Despite potential pitfalls related to mechanical or electrical interference, BIS monitor can be reliably used to monitor depth of anesthesia during individual strategic aeromedical evacuations.
Subject(s)
Aircraft , Consciousness Monitors/standards , Electroencephalography/methods , Electroencephalography/standards , Transportation of Patients/methods , Transportation of Patients/standards , Adult , Female , Humans , Male , Pilot Projects , Prospective Studies , Young AdultSubject(s)
Disseminated Intravascular Coagulation/diagnosis , Shock, Septic/diagnosis , Disseminated Intravascular Coagulation/complications , Humans , Male , Middle Aged , Shock, Septic/etiology , Streptococcal Infections/complications , Streptococcal Infections/diagnosis , Streptococcus pneumoniae/isolation & purificationABSTRACT
We report a case of scorpion envenomation occurring during combat in Tagab district, province of Kapisa, Afghanistan. A French soldier was stung by a yellow scorpion (suspected Androctonus australis) and sustained systemic envenomation with hemodynamic and neurological manifestations. We discuss the clinical features, prevention, and management of a scorpion sting.
