Successful Treatment of Superior Sagittal Sinus Thrombosis. Direct Thrombolysis with Local Infusion of t-PA via Venography in the Acute Phase.

SUMMARY: A 22-year-old pregnant women showed a rapid deterioration in her clinical condition. Superior sagittal sinus thrombosis was diagnosed, and direct transvenous infusion of t-PA into the superior sagittal sinus was performed. This treatment resulted in recanalization of the occluded superior sagittal sinus and in a dramatic improvement of neurological deficits.