ABSTRACT
Retrograde cerebral perfusion (RCP) is used to prolong the safe period of circulatory arrest under profound hypothermia. However, this technique now varies in some maneuvers at different institutions. This study investigated the effects on cerebral metabolism of clamping blood flow through the IVC cannula during RCP using fourteen adult mongrel dogs. During circulatory arrest, RCP by way of the bilateral internal maxillary vein was performed. In seven dogs, blood flow was drained through IVC cannula (IVC-drained group) and in the other seven dogs, the blood flow was clamped during RCP (IVC-clamped group). During RCP, the percent of returned blood volume, oxygen consumption, exudation of carbon-dioxide, and oxygen saturation of the returned blood were significantly higher in the IVC-clamped group than in the IVC-drained group, and the concentration of serum CK-BB in the IVC-clamp group was significantly lower than in the IVC-drained group. However, there was no statistical difference between the two groups concerning the regional cerebral blood flow or water content of the cerebral tissue. Concerning about these results, a part of perfused blood passed through not only the extra cranial veno-venous connection but also the intra cranial veno-capillary-venous connection. We concluded that clamping of the venous blood flow through the IVC cannula during RCP is a more protective procedure for cerebral tissue.
Subject(s)
Cerebrovascular Circulation , Hypothermia, Induced , Perfusion , Animals , Body Water/metabolism , Brain/metabolism , Carbon Dioxide/metabolism , Catheterization , Dogs , Extracorporeal Circulation/methods , Oxygen Consumption , Vena Cava, InferiorABSTRACT
A diagnosis of diffuse esophageal spasm (DES) based on radiological and manometric studies was made in a 70-year-old man who presented with severe dysphagia, vomiting, and spontaneous chest pain. The manometric studies revealed a simultaneous onset of high amplitude contractions and a hypertensive lower esophageal sphincter (LES) that was well relaxed in response to deglutition, in contrast to the incomplete relaxation seen in achalasia. Because his dysphagia was so severe and did not respond to pneumatic dilatation, the patient was treated by a long esophageal myotomy with a full thickness incision through the LES and mucosa, adding a Thal-Hatafuku procedure. The patient made a good postoperative recovery and has since been eating normally without any further dysphagia or chest pain. Good manometric and radiological results have been obtained in this patient during 5 years of follow-up.
