Osteoporosis, an Inevitable Circumstance of Chronic Kidney Disease: A Systematic Review.

Nowadays, chronic kidney disease (CKD) and osteoporosis have become crucial health-related issues globally. CKD-induced osteoporosis is a systemic disease characterized by the disruption of mineral, hormone, and vitamin homeostasis that elevates the likelihood of fracture. Here, we review recent studies on the association of CKD and osteoporosis. In particular, we focus on the pathogenesis of CKD-associated osteoporosis, including the homeostasis and pathways of several components such as parathyroid hormone, calcium, phosphate, vitamin D, fibroblast growth factor, and klotho, as well as abnormal bone mineralization, remodeling, and turnover. In addition, we explore the diagnostic tools and possible therapeutic approaches for the management and prevention of CKD-associated osteoporosis. Patients with CKD show higher osteoporosis prevalence, greater fracture rate, increased morbidity and mortality, and an elevated occurrence of hip fracture. We also rule out that increased severity of CKD is related to a more severe condition of osteoporosis. Furthermore, supplements such as calcium and vitamin D as well as lifestyle modifications such as exercise and cessation of smoking and alcohol help in fracture prevention. However, new approaches and advancements in treatment are needed to reduce the fracture risk in patients with CKD. Therefore, further collaborative multidisciplinary research is needed in this regard.

Association between physical activity and diabetic complications among Bangladeshi type 2 diabetic patients.

BACKGROUND: The aim of the study was to assess the association of physical activity (PA) with the presence of diabetes related complications among Bangladeshi type 2 diabetic subjects. METHODS: This cross-sectional study was conducted in the Out Patient Department (OPD) of BIRDEM, Bangladesh. A group of 977 subjects were randomly selected and followed up. Diabetes was diagnosed following the WHO study group criteria. The level of PA was categorized into inactive/low (<150 min/week) and moderate-to-vigorous (≥150 min/week). The WHO recommended Asian criteria was used to identify general obesity. Retinopathy was detected by fundal photography, CKD by serum creatinine and hypertension was diagnosed clinically. Univariate and multivariate analyses were used to assess the associations of PA with diabetes related complications. RESULTS: Out of the 977 subjects investigated, 468 were male and 509 were female (mean ±â€¯SD of age, 56 ±â€¯8 years). In the study subjects, 74% were either inactive or in low PA and of them 65.1% were overweight/obese. Analysis showed that inactive/low PA was associated with all the three diabetes related complications (p < 0.001)-hypertension, retinopathy, and nephropathy. Multivariate analysis showed that inactive/low level of PA was strongly associated with complications like retinopathy (p < 0.001) and hypertension (p = 0.01) in the female patients. It was also found to be highly associated with retinopathy (p < 0.001) among the male patients. CONCLUSION: A large number of urban Bangladeshi population are involved only in low PA or remain inactive themselves, which is leading to obesity and it seems to have a strong association with diabetes related complications in this population.