ABSTRACT
The liver microsomal metabolism of the environmental carcinogen 3-nitrofluoranthene has been investigated. Five phenolic metabolites were isolated and characterized by their mass and NMR spectra as: 3-nitrofluoranthen-1-ol, 3-nitrofluoranthen-6-ol, 3-nitrofluoranthen-(7 or 10)-ol, 3-nitrofluoranthen-8-ol and 3-nitrofluoranthen-9-ol. While the microsomes isolated from Sprague-Dawley rat liver and C57B16 mouse liver preferentially metabolized the 3-nitrofluoranthene to 3-nitrofluoranthen-8-ol and 3-nitrofluoranthen-9-ol, the microsomes from Hartley guinea-pig liver preferentially metabolized 3-nitrofluoranthene to 3-nitrofluoranthen-6-ol. 3-Nitrofluoranthen-1-ol was a minor metabolite in each of the incubations. The results indicate the presence of the nitro group on fluoranthene directs the metabolism away from the C1-C5 positions, and more towards the C6-C10 positions.
Subject(s)
Air Pollutants , Fluorenes/metabolism , Microsomes, Liver/metabolism , Animals , Cricetinae , Female , Goats , Guinea Pigs , Magnetic Resonance Spectroscopy , Male , Mesocricetus , Mice , Mice, Inbred C57BL , Phenols/isolation & purification , Rats , Rats, Inbred StrainsABSTRACT
The present paper reports on a Q fever outbreak of 149 cases in a municipal slaughter house focus. The diagnosis was established by clinical, epidemiological, radiologic and laboratory investigations. The route of transmission was air-borne from the sick animals (not detected at the veterinary control) to man. A closer cooperation is recommended between the human and veterinary health services, for early detection of the cases, their prevention and control. The authors suggest the need to immunize the personnel exposed to the risk of contamination (zoo technical units, slaughter house personnel, etc.).
