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1.
Dermatol Online J ; 29(6)2023 Dec 15.
Article in English | MEDLINE | ID: mdl-38478665

ABSTRACT

A 9-year-old boy diagnosed with acute myeloblastic leukemia and undergoing chemotherapy, was admitted with febrile neutropenia. During his admission, several violaceous plaques appeared on the upper extremities and anterior left hemithorax, which worsened and acquired a necrotic center. We performed a biopsy and histology showed a cutaneous infarction at the dermoepidermal and subcutaneous level. We observed abundant wide hyphae with right-angled branching and a culture isolated Rhizopus oryzae. A plastic surgery consultant performed a surgical debridement of the lesions and treatment was started with intravenous amphotericin B. The patient did well on treatment and after almost a month of hospitalization, he was discharged with oral posaconazole. Mucormycosis is an opportunistic fungal infection associated with immunosuppression, particularly involving prematurity and hematological diseases in the pediatric age group. Multiple lesions, as in our case, are infrequent. The clinical presentation is variable. Direct smear or histological observation is the quickest diagnostic technique whereas culture is the most definitive. The combination of surgical debridement and amphotericin B is the treatment with the highest survival rates.


Subject(s)
Amphotericin B , Mucormycosis , Male , Humans , Child , Amphotericin B/therapeutic use , Rhizopus , Mucormycosis/diagnosis , Mucormycosis/therapy , Skin/pathology , Necrosis/complications , Antifungal Agents/therapeutic use
3.
Chirurgia (Bucur) ; 117(2): 211-217, 2022 Apr.
Article in English | MEDLINE | ID: mdl-35535783

ABSTRACT

The ischemic complications during the isolation of the substituting oesophageal graft placement and after its placement may lead to graft necrosis and to the need to find a different reconstructive procedure. The most frequent reports of graft necroses occur in the days following the reconstruction. We are presenting the case of a 27-y.o. with full dysphagia as a result of caustic stenosis, in whose case the oesophageal reconstruction was abandoned following the irreversible ischemia of the right colic graft during the vascular isolation, followed by right-side hemicolectomy and ileo-transverse anastomosis. 4 years post the ingestion of a caustic substance and 2 years post the right colic graft ischemic necrosis, we performed an oesophageal reconstruction using a pediculated, cervically revascularized, ileo-colic graft on the left colic vessels. The graft's particularity is that is formed from left and transverse colon and ileum portions, including the ileo-transverse anastomosis performed 2 years prior to the oesophageal reconstruction.


Subject(s)
Caustics , Colic , Esophagoplasty , Anastomosis, Surgical/methods , Colic/surgery , Colon/transplantation , Esophagoplasty/methods , Humans , Ileum/surgery , Necrosis , Treatment Outcome
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