Effect of glycerol and dibutyl phthalate on modified natural rubber latex based drug delivery systems.

The work highlights the impact of the incorporation of two pharmaceutical plasticizers viz.; glycerol (GLY; hydrophilic) and dibutyl phthalate (DBP; hydrophobic) on the controlled drug release features of a deproteinised natural rubber latex (DNRL) -based matrix. The effects of the plasticizers on the mechanical properties, glass transition temperature (Tg), water absorption behaviour and porosity of DNRL have been initially investigated. The plasticized membranes have been found to show a hemolysis percentage (HP) of <5 %; confirming its compatibility with human blood. The potential of the modified DNRL membranes to function as drug carriers have been examined with metformin hydrochloride (MET) as a model drug.