1.
Chem Commun (Camb)
; 47(13): 3975-7, 2011 Apr 07.
Article
in English
| MEDLINE
| ID: mdl-21347494
ABSTRACT
A concise synthesis of a highly functionalized intermediate lacking only C10 of the mitomycin backbone is described. The key to this development is the Brønsted acid-catalyzed aza-Darzens reaction used to forge the cis-aziridine. Additionally an oxidative ketalization fortuitously occurs during the quinone-enamine coupling step, leading to an orthogonally protected hydroquinone.