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BMJ Case Rep ; 20182018 Jul 30.
Article in English | MEDLINE | ID: mdl-30061135

ABSTRACT

Hodgkin's lymphoma (HL) is a type of cancer originating in the lymph nodes. The preferred therapy for advanced HL is a combination of chemotherapies including doxorubicin, bleomycin, vinblastine and dacarbazine (ABVD). ABVD has been standard therapy for advanced HL. It is generally considered as safe and rarely has been reported to cause acute liver failure. We present a case of 79-year-old woman with HL, who developed acute liver failure secondary to first cycle of ABVD chemotherapy.


Subject(s)
Antineoplastic Combined Chemotherapy Protocols/adverse effects , Chemical and Drug Induced Liver Injury/diagnosis , Hodgkin Disease/drug therapy , Immunoconjugates/therapeutic use , Syncope/chemically induced , Aged , Antineoplastic Combined Chemotherapy Protocols/administration & dosage , Bleomycin/administration & dosage , Bleomycin/adverse effects , Brentuximab Vedotin , Chemical and Drug Induced Liver Injury/complications , Dacarbazine/administration & dosage , Dacarbazine/adverse effects , Dose-Response Relationship, Drug , Doxorubicin/administration & dosage , Doxorubicin/adverse effects , Female , Humans , Treatment Outcome , Vinblastine/administration & dosage , Vinblastine/adverse effects
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