ABSTRACT
A 55-year-old male Nepali patient developed rhinaphyma. he had rosacea aAd history of intake of alcohol for a long duration.The cosmetic defect was removed by surgical repair.
Subject(s)
Encephalitis, Japanese/epidemiology , Pregnancy Complications, Infectious/epidemiology , Adolescent , Adult , Antibodies, Viral/analysis , Brain/microbiology , Disease Outbreaks/epidemiology , Encephalitis Virus, Japanese/immunology , Encephalitis Virus, Japanese/isolation & purification , Encephalitis, Japanese/immunology , Encephalitis, Japanese/microbiology , Female , Humans , India , Pregnancy , Pregnancy Complications, Infectious/immunology , Pregnancy Complications, Infectious/microbiologyABSTRACT
The present study was undertaken to investigate if the suppressed cell-mediated immune responses observed in dengue type 2 virus (DV)-infected mice could be due to the cytotoxic factor (CF) produced in the spleens of DV-infected mice. We have observed that CF given intravenously (i.v.) kills splenic cells and reduces the total cells in the spleen. Mice treated with CF have a significantly depressed immune response to sheep erythrocytes, viz. delayed-type-hypersensitivity as measured by footpad swelling reaction at 24 hr; Jerne's antibody plaque-forming cells in the spleen; and migration inhibition of spleen cells in presence of antigen. These findings are similar to those seen earlier in DV-infected mice.
Subject(s)
Cytotoxicity, Immunologic , Dengue Virus/immunology , Immunity, Cellular , Immunosuppression Therapy , Animals , Cell Migration Inhibition , Erythrocytes/immunology , Hemolytic Plaque Technique , Hypersensitivity, Delayed , Leukocytes/immunology , Mice , Spleen/immunologyABSTRACT
In previous studies we have observed the production of a cytotoxic factor by the T-lymphocytes in the spleen of dengue type-2 virus- (DV) infected mice which killed normal mouse spleen cells in vitro. In the present study types of spleen cells affected in vitro by the cytotoxic factor (CF) have been investigated. It was observed that it kills of the macrophages, one-third of T-lymphocytes and a few of the granulocytes, normoblasts and megakaryocytes. It had no effect on B-lymphocytes. The proportion of killed cells could not be significantly enhanced by retreatment of cells by additional CF. The cytotoxic activity of CF is not affected by adsorption with susceptible or non-susceptible cells. CF also kills lymphoid cells of animals of other species, viz. albino rats, rabbits, guinea pigs but had no effect on those of rooster. It had no effect on various cell cultures.
