Subject(s)
Health Physics/trends , Radiation Oncology/trends , Europe , Humans , Russia , Social Change , United StatesABSTRACT
The efficiency of remaxol for prevention and treatment of chemoradiotherapy toxicity effects in patients with advanced oral cancer was evaluated. Ninety-five oral cancer patients were using remaxol both locally (mouth rinse solution) and by intravenous infusion, 87 patients were included in control group. Intravenous remaxol proved to be effective for mucositis and nephrotoxicity prevention by chemoradiotherapy.
Subject(s)
Chemoradiotherapy/adverse effects , Mouth Neoplasms/therapy , Mouthwashes/administration & dosage , Succinates/administration & dosage , Administration, Intravenous , Adult , Aged , Aged, 80 and over , Female , Gastric Mucosa/drug effects , Gastric Mucosa/radiation effects , Humans , Kidney/drug effects , Kidney/radiation effects , Male , Middle Aged , Mouth Mucosa/drug effects , Mouth Mucosa/radiation effects , Radiation Injuries/drug therapy , Radiation Injuries/etiology , Retrospective Studies , Stomatitis/drug therapy , Stomatitis/etiologyABSTRACT
The article discusses the practice of detoxication therapy to minimize undesirable toxic effects during chemo- and radiotherapy for locally advanced cancer of the oral mucosa in 88 patients treated with 1.5% solution of reamberine. There was a significant improvement in the parameters of liver function, as well as in the general wellbeing of patients. We analyzed the main symptoms of the toxicity of chemo- and radiotherapy in both groups. Inclusion of the reamberine solution as supportive therapy for cancer patients who were receiving chemo- and radiotherapy for cancer of the oral mucosa allowed reducing the number and severity of toxic complications.
Subject(s)
Antineoplastic Combined Chemotherapy Protocols/adverse effects , Liver/drug effects , Meglumine/analogs & derivatives , Mouth Mucosa/drug effects , Mouth Neoplasms/drug therapy , Mouth Neoplasms/radiotherapy , Stomatitis/etiology , Stomatitis/prevention & control , Succinates/therapeutic use , Adult , Aged , Antineoplastic Combined Chemotherapy Protocols/administration & dosage , Chemotherapy, Adjuvant/adverse effects , Female , Humans , Liver/metabolism , Male , Meglumine/therapeutic use , Middle Aged , Radiotherapy, Adjuvant/adverse effects , Severity of Illness Index , Stomatitis/chemically induced , Stomatitis/diagnosis , Treatment OutcomeABSTRACT
The paper is concerned with the results of extended and combined operations on 58 patients, subjected to a previous radical course of beta-beam or combined (external and contact) irradiation for cancer of the oral cavity and oropharyngeal organs. Over 2 years after operation 50% of the patients are alive. Twenty-two patients died of tumor relapse, regional or distant metastases, one patient died of another tumor site, and 6 patients died from intercurrent diseases. The results obtained are indicative of the appropriateness of this kind of operations. The use of plastic surgery simultaneously with the removal of a primary tumor prevents severe postoperative complications.
Subject(s)
Jaw Neoplasms/radiotherapy , Jaw Neoplasms/surgery , Mouth Neoplasms/radiotherapy , Mouth Neoplasms/surgery , Tongue Neoplasms/radiotherapy , Tongue Neoplasms/surgery , Combined Modality Therapy , Humans , Neck Dissection , Neoplasm Metastasis , Prognosis , Radiotherapy Dosage , Surgical FlapsABSTRACT
ICO - 10 (Thy-1 antigen) and K 20 (gp 120/200) monoclonal antibodies proved suitable for immunophenotyping solid tumors. The following typical antigen combinations were identified with regard to reaction with those antibodies: ICO - 10+ K 20- (neuroblastoma, malignant schwannoma, neurosarcoma and soft tissue sarcomas); K 20+ ICO - 10- (cancer of the tongue and esophagus, adenoma of the adrenal cortex, adenocarcinoma of the stomach, hepatoblastoma and nephroblastoma); ICO - 10+ K 20+ (immature teratoma and cervical and esophageal leiomyoma) and ICO - 10+ K 20- (malignant fibrous histiocytoma).
Subject(s)
Antibodies, Monoclonal , Neoplasms/diagnosis , Antigens, Differentiation , Diagnosis, Differential , Female , Humans , Immunologic Tests , Isoantibodies , Neoplasms/immunology , Neoplasms/pathology , T-Lymphocytes/immunologyABSTRACT
Combined treatment of patients with cancer of the oral mucosa using a dynamic course of irradiation in combination with local hyperthermia was proposed. Altogether 55 patients were treated, of them in 51 (92.7%) complete tumor regression was achieved. The short-term results were indicative of the efficacy of the above method.
Subject(s)
Carcinoma, Squamous Cell/therapy , Diathermy , Mouth Neoplasms/therapy , Short-Wave Therapy , Adult , Aged , Carcinoma, Squamous Cell/radiotherapy , Combined Modality Therapy , Female , Humans , Male , Middle Aged , Mouth Neoplasms/radiotherapySubject(s)
Mouth/radiation effects , Radiation Injuries/etiology , Brachytherapy/adverse effects , Carcinoma, Squamous Cell/complications , Carcinoma, Squamous Cell/radiotherapy , Combined Modality Therapy/methods , Humans , Mouth Floor , Radiation Injuries/diagnosis , Radiation Injuries/therapy , Radioisotope Teletherapy/adverse effects , Radiotherapy Dosage , Tongue Neoplasms/complications , Tongue Neoplasms/radiotherapyABSTRACT
The authors presented the immediate and 3-year results of interstitial and combined therapy of 90 patients with cancer of the tongue and oral fundus mucosa. 60Co- and 252Cf-sources were employed in interstitial radiotherapy. There were no significant differences in therapeutic efficacy using different radiation sources. Some methodological aspects of administration of interstitial radiotherapy, radiation reactions and complications were covered.
Subject(s)
Brachytherapy , Californium/therapeutic use , Cobalt Radioisotopes/therapeutic use , Mouth Neoplasms/radiotherapy , Tongue Neoplasms/radiotherapy , Adult , Aged , Carcinoma, Squamous Cell/radiotherapy , Female , Humans , Male , Middle Aged , Mouth FloorSubject(s)
Californium/adverse effects , Fast Neutrons/adverse effects , Neutrons/adverse effects , Radiation Injuries/etiology , Radiotherapy/adverse effects , Administration, Topical , Adult , Aged , Dose-Response Relationship, Radiation , Humans , Lip Neoplasms/radiotherapy , Middle Aged , Mouth Neoplasms/radiotherapy , Neoplasm Recurrence, Local/radiotherapy , Skin Neoplasms/radiotherapy , Soft Tissue Neoplasms/radiotherapy , Time FactorsSubject(s)
Head and Neck Neoplasms/diagnosis , Paraganglioma, Extra-Adrenal/diagnosis , Adult , Aged , Carotid Body Tumor/blood supply , Carotid Body Tumor/diagnosis , Cranial Nerve Neoplasms/blood supply , Cranial Nerve Neoplasms/diagnosis , Female , Head and Neck Neoplasms/blood supply , Humans , Male , Middle Aged , Paraganglioma, Extra-Adrenal/blood supply , Vagus NerveABSTRACT
In the paper the authors report their experience with application of a jugular fatcutaneous pedicled graft for primary reconstruction of defects of the oral mucous membrane following resection of localy spread malignant tumors under conditions of preliminary radiotherapy. Results of the plasty in 30 patients are reported. The technic of cutting out the graft is described.
