Influence of subacute physical exercise on medium- and long-chain fatty acid profile in serum of individuals with overweight / Influencia del ejercicio físico subagudo en el perfil de ácidos grasos de cadena media y larga en individuos con sobrepeso

Objective: to test the hypothesis that acute physical exercise would change the fatty acids in the serum of individuals with increased body weight. Method: sixty-six sedentary women with excess weight were included in the sample (BMI = 29.6 ± 4.2). They were aged 24.4 ± 3.6 years and were randomly divided into control and exercise groups. After 12 hours fasting, basal blood collection was performed. Twelve hours after the first collection, the exercise group was submitted to a physical exercise session with energy expenditure of 250 kcal. The volunteers underwent a second blood collection 24 hours after the first one and dosed the fatty acids: pelargonic, azelaic, elaidic and oleic. Results: physical exercise did not change the fatty acid profile response for both the intragroup analysis and intergroup analysis. Exercise group: pelargonic (before = 0.12 ± 0.06% vs after = 0.15 ± 0.14%, p = 0.507); azelaic (before = 20.3 ± 10.5% vs after = 27.7 ± 25.4%, p = 0.295); elaidic (before = 0.03 ± 0.01% vs after = 0.04 ± 0.01%, p = 0.328); oleic (before = 16.1 ± 7.4% vs after = 20.3 ± 14.6%, p = 0.236). Control group: pelargonic (before = 0.70 ± 0.45% vs after = 0.71 ± 0.51%, p = 0.776); azelaic (before = 62.1 ± 26% vs after = 57.1 ± 27%, p = 0.197); elaidic (before = 0.05 ± 0.02% mg/dl vs after = 0.05 ± 0.03%, p = 0.530); oleic (before = 26.8 ± 22.7% mg/dl vs after = 29.0 ± 22.4%, p = 0.525). Conclusion: in women with overweight, low intensity physical exercise is not capable of changing the medium-chain fatty acids in the first 12 hours

Objetivo: probar la hipótesis de que ejercicio físico agudo cambiaría los ácidos grasos en el suero de las personas con mayor peso corporal. Método: se incluyeron en la muestra sesenta y seis mujeres sedentarias con exceso de peso (IMC = 29.6 ± 4.2). Tenían una edad de 24,4 ± 3,6 años y se dividieron aleatoriamente en grupos de control y ejercicio. Después de 12 horas de ayuno, se realizó la extracción de sangre basal. Doce horas después de la primera extracción, el grupo de ejercicio se sometió a una sesión de ejercicio físico con un gasto de energía de 250 kcal. Los voluntarios se sometieron a una segunda extracción de sangre 24 horas después de la primera con dosificación de los ácidos grasos: pelargónico, azelaico, elaídico y oleico. Resultados: el ejercicio físico no modificó la respuesta del perfil de ácidos grasos para el análisis intragrupo y el análisis intergrupo. Ejercicio grupo: pelargónico (antes = 0,12 ± 0,06% vs después = 0,15 ± 0,14%, p = 0,507); azelaico (antes = 20,3 ± 10,5% vs después = 27,7 ± 25,4%, p = 0,295); elaídico (antes = 0,03 ± 0,01% vs después = 0,04 ± 0,01%, p = 0,328); oleico (antes = 16,1 ± 7,4% vs después = 20,3 ± 14,6%, p = 0,236). Grupo de control: pelargónico (antes = 0,70 ± 0,45% vs después = 0,71 ± 0,51%, p = 0,776); azelaico (antes = 62,1 ± 26% vs después = 57,1 ± 27%, p = 0,197); elaídico (antes = 0,05 ± 0,02% mg/dl vs después = 0,05 ± 0,03%, p = 0,530); oleico (antes = 26.8 ± 22,7% mg/dl vs después = 29,0 ± 22,4%, p = 0,525). Conclusión: en mujeres con sobrepeso, el ejercicio físico de baja intensidad no produce ningún cambio en los ácidos grasos de cadena media en las primeras 12 horas

Metabolic Reponses to a physical exercise session in women with excess body mass: randomized clinical trial.

BACKGROUND: There are various factors that influence the effect of physical exercise on the lipid profile, among them the body mass index and calorie expenditure of the exercise are some of the main factors. To test the hypothesis that a physical exercise session based on caloric expenditure may acutely modify the glycemia and lipid values of women with excess body mass. METHODS: The study included 66 women, randomly divided into two groups, control and experimental, with BMI of 29 ± 4.4 kg/m2 vs 29 ± 4.3 kg/m2 (p = 0.45) sedentary and aged 23 ± 3.8 vs 24 ± 3.5 years, respectively (p = 0.25). After 12 h fasting, the volunteers underwent the first blood collection. The experimental group was submitted to a physical exercise session corresponding to energy expenditure of 250Kcal, of light intensity based the Borg Rating of Perceived Exertion (RPE), 12 h after the first blood collection. The control and experimental group volunteers underwent a second blood collection 24 h after the first. Glycemia, insulin status and lipid profile were measured and Homa IR and Homa-beta were calculated. The t-test for independent and dependent samples was used, and a level of significance of 5% was adopted. RESULTS: Physical exercise changed the glycemic response in both the intragroup analysis (before = 96 ± 6.6 mg/dL vs after = 92 ± 6.6 mg/dL), (p = 0.01), and in the intergroup analysis (control = Δ 0.9 ± 6.1 vs experimental = Δ -4.1 ± 6.3) (p = 0.02). No changes were shown for the Homa IR, Homa Beta and Insulin indexes. When the lipid profiles were evaluated, differences in HDL were shown in the intragroup analysis (before = 89 ± 10.5 mg/dL vs. after = 91 ± 10.3 mg/dL) (p = 0.04). For the other parameters (LDL, TG, Total Cholesterol, TG/HDL), no changes were shown. CONCLUSION: In women with excess body weight, a low intensity exercise session diminished the glycemia, but did not change the lipid response. TRIAL REGISTRATION: NCT03170973 . Retrospectively registered.