ABSTRACT
OBJECTIVES: Unlike rheumatic fever (RF), the association of post-streptococcal reactive arthritis (PSRA) and carditis is controversial. The American Heart Association recommends anti-streptococcal prophylaxis for PSRA for one year, repeating echocardiogram and discontinuation of prophylaxis if normal. In this study the possibility of late cardiac involvement was investigated in a cohort of children with PSRA. METHODS: Children diagnosed with PSRA and followed at the Paediatric Rheumatology Units at two medical centres in Israel had echocardiography carried out by a paediatric cardiologist, at least 1 year following diagnosis. RESULTS: 146 patients with PSRA met the study criteria. Of these, 69 had undergone echocardiography 1-6.9 years (mean 3.6 years ± 1.5 years) after diagnosis. All had normal major parameters. Twenty (29.0%) patients had minimal cardiac findings, including 5 (7.2%) mild mitral insufficiency, 12 (17.4%) minimal mitral insufficiency, 2 (2.9%) mild tricuspid insufficiency and one patient (1.4%) had very mild, aortic insufficiency. Of the 77 patients who did not have echocardiography, 31 were randomly excluded from the initial study list, 26 refused to undergo echocardiography, and 20 were lost to follow-up. All were asymptomatic according to their medical record or telephone questionnaire. There were no significant differences in clinical or demographic data between those with or without echocardiography. CONCLUSIONS: No late cardiac involvement was found in our paediatric PSRA patients. Therefore, different approaches to antibiotic prophylaxis for PSRA and ARF are probably suggested. A prospective, controlled study is needed to definitively assess the necessity of prophylaxis in PSRA.
Subject(s)
Anti-Bacterial Agents/therapeutic use , Arthritis, Reactive , Myocarditis , Post-Exposure Prophylaxis/methods , Streptococcal Infections/complications , Arthritis, Reactive/complications , Arthritis, Reactive/diagnosis , Arthritis, Reactive/epidemiology , Arthritis, Reactive/microbiology , Child , Echocardiography/methods , Female , Follow-Up Studies , Humans , Israel , Male , Monitoring, Physiologic/methods , Monitoring, Physiologic/statistics & numerical data , Myocarditis/diagnosis , Myocarditis/epidemiology , Myocarditis/etiology , Myocarditis/microbiology , Myocarditis/prevention & control , Patient Outcome Assessment , Time FactorsABSTRACT
Sydenham's chorea occurs in approximately 10% of acute rheumatic fever and is one of its major manifestations. The disease may last for weeks or months, with a high risk of recurrence; usually only supportive treatment is recommended. This report describes five children diagnosed with Sydenham's chorea and treated with a short course of corticosteroids. Marked improvement of the involuntary movements was observed within 24-48 hours, with complete resolution within 7-12 days after commencement of treatment; there were no relapses. Larger, possibly comparative studies are necessary, but in the meantime treatment with corticosteroids in patients with Sydenham's chorea should be considered.
Subject(s)
Chorea/drug therapy , Glucocorticoids/administration & dosage , Prednisone/administration & dosage , Administration, Oral , Child , Child, Preschool , Chorea/microbiology , Drug Administration Schedule , Female , Humans , Male , Rheumatic Fever/complicationsABSTRACT
We report a case of an infant with an extensive hemangioma encompassing the thoracic aorta, associated with complex coarctation. Surgical approach was abandoned for fear of bleeding. The complexity of the coarctation made it unsuitable for balloon dilation. We implanted a stent with significant angiographic improvement and resolution of systemic hypertension.
