[Normovolemic hemodilution during surgical revascularization of the myocardium]. / Normovolemicheskaia gemodiliutsiia pri khirurgicheskoi revaskuliarizatsii miokarda.

The hemodynamic efficiency of hydroxyethyl tarch 130/0.4 "Voluven" (HET) was investigated within a method of acute normovolemic hemodilution in 11 patients with ischemic heart disease (IHD) during the implementation of surgical revascularization of the myocardium under the conditions of extracorporeal artificial blood circulation. It was shown, that in case of invasive monitoring of central hemodynamic and of the oxygen-transport function of the blood circulation system, an exfusion of 13.28 +/- 1.53 ml/kg can be regarded as a permissible blood-saving procedure in IHD patients during revascularization of the myocardium. The application of HET 130/0.4 "Voluven" provides for an adequate correction of shifts in the blood circulation system and in its oxygen function--such shifts occur in implementing the acute normovolemic hemodilution in IHD patients.

[Therapy of arterial hypertension with verapamil hydrochloride in patients after myocardial revascularization]. / Korrektsiia arterial'noi gipertenzii verapamilom gidrokhloridom u bol'nykh posle revaskuliarizatsii miokarda.

Verapamil hydrochloride, a calcium blocker from a group of phenyl alkylamines, was tested for its effect on central hemodynamics (CH) and blood oxygen-transporting function (BOTF) in 14 patients with arterial hypertension after surgical myocardial revascularization. CH and BOTF were studied by using a Swan-Hanz catheter and directly measuring blood pressure (BP). There was a significant reduction in BPmean, total peripheral vascular resistance index, left ventricular stroke outcome index, and oxygen delivery index. Verapamil in an average dose of 80.4 +/- 18.02 mg at the injection rate of 24.6 +/- 3.9 micrograms/kg/min was shown to make BPmean normal 16.8 +/- 6.35 min later. The agent is comparable with other calcium blockers, such as nifedipine and isradipine in its action on CH and BOTF, as well as in its efficiency and safety.

[Lomir in the treatment of arterial hypertension after angioplastic surgery]. / Lomir v lechenii arterial'noi gipertenzii posle angioplasticheskikh operatsii.

Isradipine (lomir) is a new highly selective arteriolar vasodilator of the dihydropyridine group, characterized by a slight cardiodepressive effect. The drug effect on the central hemodynamics and oxygen transport was studied after cardiovascular surgery. Arterial pressure and total peripheral vascular resistance were reliably reduced at the peak of the drug action, as was the left-ventricular stroke work and oxygen consumption. A tendency to increase of cardiac output and cardiac index was observed. Pulmonary vascular resistance and pressure in the pulmonary artery did not reliably change. The drug increased the intrapulmonary shunt.