ABSTRACT
The effect of ternatin, a tetramethoxyflavone from Egletes viscosa Less., on liver injury induced by carbon tetrachloride (CCl4) was investigated in rats. Twenty-four hours following CCl4 insult (2.5 ml/kg s.c.), changes in the serum enzymes, alanine aminotransferase, aspartate aminotransferase and gamma-glutamyltransferase, as well as liver cell histology were used as indices of hepatic dysfunction. The results show that ternatin (30 mg/kg i.p. daily for 5 consecutive days) causes marked inhibition of CCl4-induced serum enzymes and morbid histologic changes. The observation suggests that ternatin possesses antihepatotoxic activity.
Subject(s)
Flavonoids/pharmacology , Liver/drug effects , Plants, Medicinal , Alanine Transaminase/metabolism , Animals , Aspartate Aminotransferases/metabolism , Carbon Tetrachloride/pharmacology , Male , Plant Extracts , Rats , Rats, Wistar , gamma-Glutamyltransferase/metabolismABSTRACT
Descriptive exploratory study accomplished with the purpose of identifying nurses' scientific productions in the Northeast Region during the period of 1988-1992, checking the rind of papers presented, the predominating theme area and the divulgation used. We observe that there is a sensitive increase in these productions since 1990. Scientific articles and assistentcal area themes predominated, as did the divulgation through national events.
