[Diabetes mellitus and tumors of the oral cavity--epidemiologic correlations]. / Diabetes mellitus és a szájüregi daganatok epidemiológiai összefüggései.

INTRODUCTION AND AIMS: Numerous publications have already demonstrated that diabetes mellitus (DM) is a risk factor for the development of periodontal diseases and various inflammatory lesions in the oral mucosa. A possible correlation between DM and oral premalignancies and tumors was examined in this study, as no literature data are available concerning this problem. METHODS: Stomato-oncological screening was carried out on 200 DM patients in the medical departments: The lesions found were classified in three groups: inflammatory lesions, benign tumors and precancerous lesions. Benign tumors were found in 14.5%, and precancerous lesions in 8% of diabetics. Earlier Hungarian screening studies indicated lower frequency of these lesions in the general population. A retrospective DM screening of 610 inpatients with histologically confirmed oral malignancies was also performed. The control group comprised 574 complaint- and tumor-free adults. Fasting blood glucose levels were determined in both groups, and the tumor location was registered in the cancer patients. RESULTS: In the group of the oral cancer patients, DM was present in 14.6% and an elevated blood glucose level in 9.7%. These values are significantly higher than those for the tumor-free control group (p < 0.01). The gingival and labial tumor location was significantly more frequent among diabetic cancer patients than in the non-diabetic group (p < 0.01). CONCLUSION: The combination of DM and smoking means a higher risk for oral precancerous lesions and malignancies. DM may be a risk factor for oral premalignancies and tumors.

Diabetes and oral tumors in Hungary: epidemiological correlations.

OBJECTIVE: Numerous publications have already demonstrated that diabetes is a risk factor for the development of periodontal diseases and various inflammatory lesions in the oral mucosa. A possible correlation between diabetes and oral premalignancies and tumors was examined in this study, as no literature data are available concerning this problem. RESEARCH DESIGN AND METHODS: Stomato-oncological screening was carried out on 200 diabetic patients in the medical departments; the control group included 280 adult dentistry outpatients. The lesions found were classified into three groups: inflammatory lesions, benign tumors, and precancerous lesions. A retrospective diabetes screening of 610 inpatients with histologically confirmed oral malignancies was also performed. The control group comprised 574 complaint- and tumor-free adults. Fasting blood glucose levels were determined in both groups, and the tumor location was registered in the cancer patients. RESULTS: Benign tumors were found in 14.5% and precancerous lesions in 8% of diabetic patients. In the control group these values were significantly lower, at 6.4 and 3.2%, respectively (P>0.01). Earlier Hungarian screening studies indicated similar frequency of these lesions in the general population. The proportion of oral cavity lesions was higher among diabetic patients compared with that of the control patients. In the oral cancer patient group, diabetes was present in 14.6% and an elevated blood glucose level in 9.7%. These values are significantly higher than those for the tumor-free control group (P<0.01). The gingival and labial tumor location was significantly more frequent among diabetic cancer patients than in the nondiabetic group (P<0.01). The combination of diabetes and smoking means a higher risk for oral precancerous lesions and malignancies. CONCLUSIONS: Diabetes may be a risk factor for oral premalignancies and tumors.

[Stomato-oncological screening in diabetic patients]. / Stomatoonkológiai szúróvizsgálat cukorbetegek esetében.

The data of the literature suggest that studies have not been performed to date on possible correlations between diabetes and precancerous states and tumors in the oral cavity. Internationally, only one investigation appears to have dealt with the incidence of leukoplakia among diabetics. In the present work, stomato-oncological screening was performed on 200 treated diabetics. Precancerous lesions were found in 8%, and benign lesions in 14.5%. Comparison with earlier Hungarian screening studies indicated that benign and precancerous lesions occur with greater frequency among diabetics than in the average population. The proportion of oral cavity lesions is higher among diabetics of type 2 than among those of type 1. The combination of diabetes mellitus and smoking means an enhanced risk from the aspect of precancerosis of the oral cavity.

[Incidence of diabetes mellitus in patients with malignant tumors of the oral cavity]. / A diabetes mellitus elófordulása malignus szájüregi daganatos betegekben.

Diabetes mellitus affects 5% of the population of Hungary. Its complications in the oral cavity include parodontosis and changes in the oral mucosa (leukoplakia, lichen oris and glossitis). The incidence of leukoplakia (the most frequent precancerous state in the oral cavity) is 2.2% in the normal population, 6.2% among diabetics, and 11.5% among diabetic who smoke. The various forms of leukoplakia in the oral cavity become malignant in 5-20% of the cases, while the erosive, ulcerative lesions do so in 15-20% of the cases. These data led us to examine the blood glucose levels in 318 patients with histologically confirmed malignant tumours in the oral cavity. Diabetes mellitus was found in 56 of them (17.5%), the blood glucose level being elevated in 31 cases (9.75%). The fact that the incidence of diabetes mellitus among these patients was more than 3 times higher than that for the normal population demonstrates that further studies should be performed on the connection between diabetes mellitus and malignant tumours in the oral cavity.