ABSTRACT
In this paper we searched for vertebral deformities in a group of 70 premenopausal systemic lupus erythematosus (SLE) patients (31.8 +/- 8.1 years old) and compared them to a matched control group of 22 healthy women (32.0 +/- 8.9 years old). Patients and controls performed spine X-ray (XR) morphometry and lumbar spine and femoral neck bone mineral density (BMD). Clinical data was obtained by a questionnaire and charts review. Thoracic or lumbar spine fracture was observed in 15 (21.4%) SLE patients, while no deformities were found in the control group (P = 0.018). BMD was not different amongst SLE patients and controls and between SLE patients with or without deformities. Although BMD could not predict what patient have deformity, seven patients (46.6%) with deformity had a lumbar spine or femoral neck Z-score less than - 1 SD [median = -0.59 (-3.72 to +0.88) and -0.20 (-4.05 to + 1.87)] respectively. In addition, we found a negative correlation between number of fracture per patient and lumbar spine and femoral neck BMD (R = 0.58, P = 0.04 and R = 0.84, P = <0.0001 respectively). No significant correlation was found between number of deformities and clinical data. This is the first study to search for vertebral deformities in SLE patients and to demonstrate a high prevalence of deformities in a relative young SLE population. These findings bring up the necessity to look for spine deformities in this group of women regardless the BMD.
Subject(s)
Lumbar Vertebrae/injuries , Lupus Erythematosus, Systemic/diagnostic imaging , Spinal Fractures/diagnostic imaging , Spinal Fractures/epidemiology , Thoracic Vertebrae/injuries , Adult , Bone Density , Case-Control Studies , Female , Femur Neck , Humans , Lumbar Vertebrae/diagnostic imaging , Lupus Erythematosus, Systemic/complications , Premenopause , Prevalence , Radiography , Spinal Fractures/etiology , Thoracic Vertebrae/diagnostic imagingABSTRACT
Os autores apresentam dois casos de tiroidite supurativa em diabéticos tipo II, enfocando a evoluçäo rápida para sepse, levando a óbito um dos pacientes. Diagnóstico precoce, uso de antibióticos e drenagem cirúrgica ampla säo necessários para impedir um curso fatal nesses pacientes. Apresentam também uma breve revisäo sobre tiroidite supurativa
Subject(s)
Humans , Female , Adult , Thyroiditis, Suppurative/complications , Diabetes Mellitus, Type 2/complications , Gram-Positive Bacterial Infections/complications , Thyroiditis, Suppurative/therapyABSTRACT
The authors report two case studies of suppurative thyroiditis in type II diabetics patients, giving emphasis to the rapid evolution for sepsis, which took one of the patients to death. An earlier diagnosis, antibiotictherapy and a large surgical drainage are essential to avoid a fatal course in these patients. A brief review of suppurative thyroiditis is also presented.
