[Correlation between some stress-realizing and stress-limiting systems in an acute period of ischemic stroke]. / Sootnoshenie nekotorykh mediatorov stressrealizuiushchikh i stresslimitiruiushchikh sistem v ostrom periode ishemichekogo insul'ta.

Concentrations of stimulating (glutamate, aspartate) and inhibitory (GAMK, glycin) amino acids were measured in cerebrospinal liquid of 67 patients with ischemic stroke. The condition of stress-realising and stress-limiting systems (SRS and SLS) was assessed by dynamics of stimulating and inhibitory amino acids. High and rapidly increasing concentration of glutamate within the first 24 h of the disease predicts a poor prognosis. Early rise of GAMK concentration is a favourable and reliable prognostic sign. Hyperactivation of glutamatergic system and deficiency of inhibitory GAMK-ergic system cause imbalance between mediators and metabolites of SRS and SLS. The severity and duration of this imbalance determine severity of clinical symptoms and outcome of the disease.

[Changes in adaptation-compensatory processes in the course of acute ischemic stroke (clinico-biochemical comparisons)]. / Izmenenie adaptatsionno-kompensatornykh protsessov v dinamike ostrogo perioda ishemicheskogo insul'ta (kliniko-biokhimicheskie sopostavleniia).

AIM: To study changes in some components of stress-realizing system (SRS) and stress-limiting system (SLS) characterizing compensatory mechanisms in acute disturbance of cerebral circulation (ADCC). MATERIAL AND METHODS: The activities of SRS and SLS were assessed in 94 patients by changes in the concentrations of glutamate, aspartate, acid phosphatase for SRS and gamma-aminobutyric acid (GABA) for SLS, respectively. RESULTS: After analysis of clinicobiochemical correlations the following clinical phases were singled out: subcompensation, moderate decompensation, severe decompensation and terminal. The phase conversion depended on quantitative changes of SRS and SLS activity. This enabled characterization of severity in certain time periods. Imbalance was revealed between SRS and SLS because of hyperactivation or hypoactivation of one of the above systems. CONCLUSION: Imbalance between SRS and SLS converts stress-syndrome from nonspecific link of adaptation into a nonspecific link of the disease pathogenesis.

[The effect of certain ions on the realization of the phase-dependent action of the vagus nerve on the heart rhythm in cats]. / O vliianii nekotorykh ionov na realizatsiiu fazozavisimogo deistviia bluzhdaiushchego nerva na ritm serdtsa koshek.

In cats, magnesium, potassium and finoptin diminished the vagal chronotropic effect whereas calcium potentiated it. In potassium chloride administration, the vagotropic action was due to a selective diminishing of the tonic component.