Forearm Posture Affects the Corticospinal Excitability of Intrinsic and Extrinsic Hand Muscles in Dominant and Nondominant Sides.

Different forearm postures can modulate corticospinal excitability. However, there is no consensus on whether handedness plays a role in such a mechanism. This study investigated the effects of 3 forearm postures (pronation, neutral, and supination) on the corticospinal excitability of muscles from the dominant and nondominant upper limbs. Surface electromyography was recorded from the abductor digiti minimi, flexor pollicis brevis, and flexor carpi radialis from both sides of 12 right-handed volunteers. Transcranial magnetic stimulation pulses were applied to each muscle's hotspot in both cerebral hemispheres. Motor-evoked potential peak-to-peak amplitude and latency and resting motor threshold were measured. The data were evaluated by analysis of variance. The level of significance was set at 5%. The resting motor threshold was similar for the 3 muscles and both sides. Motor-evoked potential peak-to-peak amplitude from flexor pollicis brevis was lower during supination, and the dominant upper limb latency was longer. The flexor carpi radialis presented lower motor-evoked potential peak-to-peak amplitudes for neutral and shorter latencies during supination. Abductor digiti minimi seemed not to be affected by posture or side. Different muscles from dominant and nondominant sides may undergo corticospinal modulation, even distally localized from a particular joint and under rest.

Motor potential evoked by transcranial magnetic stimulation depends on the placement protocol of recording electrodes: a pilot study.

OBJECTIVE: There seems to be no consensus in the literature regarding the protocol of surface electromyography (sEMG) electrode placement for recording motor evoked potentials (MEP) in transcranial magnetic stimulation (TMS) applications. Thus, the aim of this study was to investigate the effect on the MEP amplitude bytwo different protocols for electrode placement. METHODS: sEMG electrodes were placed on three upper arm muscles (biceps brachii, flexor carpi radialis, and flexor pollicis brevis) of six right-handed subjects following two different protocols (1 and 2), which varied according to the interelectrode distance and location relative to the muscle. TMS pulses were applied to the hotspot of biceps brachii, while sEMGwas recorded from the two protocols and for each muscle simultaneously. MAIN RESULTS: Greater MEP amplitudes were obtained for Protocol 1 compared to Protocol 2 (P < 0.05). SIGNIFICANCE: Different electrode placement protocols may result in distinct MEP amplitudes, which should be taken into account when adjusting the intensity on single and repetitive TMS sessions.

Patient-specific neurosurgical phantom: assessment of visual quality, accuracy, and scaling effects.

BACKGROUND: Training in medical education depends on the availability of standardized materials that can reliably mimic the human anatomy and physiology. One alternative to using cadavers or animal bodies is to employ phantoms or mimicking devices. Styrene-ethylene/butylene-styrene (SEBS) gels are biologically inert and present tunable properties, including mechanical properties that resemble the soft tissue. Therefore, SEBS is an alternative to develop a patient-specific phantom, that provides real visual and morphological experience during simulation-based neurosurgical training. RESULTS: A 3D model was reconstructed and printed based on patient-specific magnetic resonance images. The fused deposition of polyactic acid (PLA) filament and selective laser sintering of polyamid were used for 3D printing. Silicone and SEBS materials were employed to mimic soft tissues. A neuronavigation protocol was performed on the 3D-printed models scaled to three different sizes, 100%, 50%, and 25% of the original dimensions. A neurosurgery team (17 individuals) evaluated the phantom realism as "very good" and "perfect" in 49% and 31% of the cases, respectively, and rated phantom utility as "very good" and "perfect" in 61% and 32% of the cases, respectively. Models in original size (100%) and scaled to 50% provided a quantitative and realistic visual analysis of the patient's cortical anatomy without distortion. However, reduction to one quarter of the original size (25%) hindered visualization of surface details and identification of anatomical landmarks. CONCLUSIONS: A patient-specific phantom was developed with anatomically and spatially accurate shapes, that can be used as an alternative for surgical planning. Printed models scaled to sizes that avoided quality loss might save time and reduce medical training costs.