1.
Kidney360
; 5(2): 237-251, 2024 Feb 01.
Article
in English
| MEDLINE
| ID: mdl-38098136
2.
Eur J Med Chem
; 45(3): 1059-67, 2010 Mar.
Article
in English
| MEDLINE
| ID: mdl-20036447
ABSTRACT
Two selective acylation methods for silybin esterification with long-chain fatty acids were developed, yielding a series of silybin 7-O- and 23-O-acyl-derivatives of varying acyl chain lengths. These compounds were tested for their antioxidant (inhibition of lipid peroxidation and DPPH-scavenging) and anti-influenza virus activities. The acyl chain length is an important prerequisite for both biological activities, as they improved with increasing length of the acyl moiety.
Subject(s)
Antioxidants/pharmacology , Antiviral Agents/pharmacology , Orthomyxoviridae/drug effects , Silymarin/pharmacology , Acylation , Animals , Cell Line , Cell Survival/drug effects , Dogs , Esterification , Fatty Acids/pharmacology , Magnetic Resonance Spectroscopy , Molecular Structure , Silybin
3.