ABSTRACT
This case study made use of semistructured interviews and a social network map to explore how adolescents with cancer develop resilience during the cancer experience. Seven adolescents with cancer aged 11 to 18 years and their mothers participated in this research. Pattern-matching logic using a 4-stage Self-Sustaining Process Model was applied to arrive at a comparative analysis. Findings indicated that initially, 5 adolescents who were told of their cancer diagnoses moved through the process during the cancer experience. Also, in newly diagnosed adolescents and in those who experienced relapse, a slight difference was noticed in terms of their response to studies and their hope levels. Second, 2 adolescents who were told of their diagnoses indirectly did not experience a complete passage through the phases comprising the process. Finally, the adolescents received social support from their families, friends, and relatives. This study suggests that an understanding of individual and cultural differences is important to improve resilience in adolescents with cancer. Because of the small sample surveyed by this research, further studies are needed to validate these conclusions and develop appropriate nursing intervention techniques.
Subject(s)
Attitude to Health/ethnology , Neoplasms/ethnology , Psychology, Adolescent , Resilience, Psychological , Self Care , Social Support , Adaptation, Psychological , Adolescent , Adolescent Behavior/ethnology , Family/ethnology , Female , Friends/ethnology , Humans , Japan , Life Change Events , Male , Models, Psychological , Morale , Neoplasms/diagnosis , Neoplasms/nursing , Nursing Methodology Research , Patient Education as Topic , Self Care/methods , Self Care/psychology , Self Efficacy , Surveys and Questionnaires , Truth DisclosureABSTRACT
5-(1,3,4-Oxadiazol-2-yl)pyrimidine derivative 1 was identified as a new class of FLT3 inhibitor from our compound library. With the aim of enhancement of antitumor activity of 2 prepared by minor modification of 1, structure optimization of side chains at the 2-, 4-, and 5-positions of the pyrimidine ring of 2 was performed to improve the metabolic stability. Introduction of polar substituents on the 1,3,4-oxadiazolyl group contributed to a significant increase in the metabolic stability. As a result, a series of compounds showed increased efficacy against MOLM-13 xenograft model in mice by oral administration.
Subject(s)
Chemistry, Pharmaceutical/methods , Oxadiazoles/chemical synthesis , Pyrimidines/chemistry , Pyrimidines/chemical synthesis , fms-Like Tyrosine Kinase 3/antagonists & inhibitors , Administration, Oral , Animals , Cell Line, Tumor , Cell Proliferation , Drug Design , Humans , Inhibitory Concentration 50 , Mice , Mice, SCID , Models, Chemical , Neoplasm Transplantation , Oxadiazoles/pharmacology , Pyrimidines/pharmacology , Structure-Activity Relationship , fms-Like Tyrosine Kinase 3/chemistryABSTRACT
A 79-year-old man who had low grade fever and general malaise was referred to our hospital on January 27, 2004. Physical examination revealed a hard fixed painless mass, measuring 10 cm in the left abdomen. Sarcoma of retroperitoneal origin was suspected preoperatively by abdominal ultrasonogram, CT, MRI and Angiography. Extended surgical treatment including left nephrectomy was performed. The tumor was histologically diagnosed as storiform-pleomorphic malignant fibrous histiocytoma (MFH) arising from perirenal tissue. Although we recommended adjuvant therapy after the excision, the patient refused. After a follow-up period of 11 months, he developed local recurrence in the left retroperitoneal space, and external irradiation was performed. He died 21 months after the operation. To our knowledge, this is the 10th case of MFH arising from perirenal tissue in Japan.
Subject(s)
Histiocytoma, Malignant Fibrous/diagnosis , Radiography, Abdominal , Retroperitoneal Neoplasms/diagnosis , Aged , Bone Neoplasms/secondary , Histiocytoma, Malignant Fibrous/pathology , Humans , Kidney/diagnostic imaging , Kidney/pathology , Lung Neoplasms/secondary , Male , Retroperitoneal Neoplasms/secondary , Tomography, X-Ray ComputedABSTRACT
A 16-year-old male patient was admitted to our hospital with traumatic luxation of right testis due to self-mutilation with a retractable knife on Apr. 20, 2004. He had been followed as temporal lobe epilepsy and suspicions of gender identify disorder by a pediatrician. He was fully oriented with a clear sensory and normal perception, but had no memory of what he had done. His parents were free of psychiatric disease, and he was the youngest in siblings of two older brothers. The laboratory examination showed no abnormal findings. Under general anesthesia, right testis was replaced in the scrotum and the scrotal wound was closed at the emergency operation. He had an attack of epilepsy and recovered by itself on the next day. He was discharged on the eighth postoperative day. After the operation, no recurrence has been seen until now. To our knowledge, this is the 37th case of male genital self-mutilation reported in the Japanese literature.
