1.
Drugs Exp Clin Res
; 12(1-3): 247-55, 1986.
Article
in English
| MEDLINE
| ID: mdl-2426073
ABSTRACT
Peplomycin was given in a dose of 5 mg daily, divided into two equal parts for intramuscular administration each morning and evening. This schedule not only augments the antitumour effect but also reduces adverse reactions to the drug. Peplomycin-mitomycin C (P-M) therapy improves the response rates in T3 and T4 cases of skin cancer, and is also effective in some N1, N3 and M1 cases. Continuous intra-arterial infusion of peplomycin, though requiring somewhat complicated procedures, is very effective against squamous cell carcinoma of the head, neck and extremities. Multidisciplinary therapy incorporating peplomycin has given a considerably higher five-year survival rate than that found in historical controls.
Subject(s)
Bleomycin/therapeutic use , Skin Neoplasms/drug therapy , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Bleomycin/administration & dosage , Bleomycin/adverse effects , Clinical Trials as Topic , Humans , Infusions, Intra-Arterial , Japan , Kinetics , Lung/drug effects , Mitomycin , Mitomycins/administration & dosage , Peplomycin , Tretinoin/administration & dosage
2.
Nihon Rinsho
; 38(3): 1760-3, 1980.
Article
in Japanese
| MEDLINE
| ID: mdl-7392249
Subject(s)
Foot Diseases/pathology , Heart Neoplasms/secondary , Melanoma/pathology , Aged , Female , Humans , Melanoma/secondary
3.
Hifuka Kiyo
; 65(3): 325-6, 1970 Nov.
Article
in Japanese
| MEDLINE
| ID: mdl-4936225