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Chem Pharm Bull (Tokyo)
; 52(9): 1153-4, 2004 Sep.
Article
in English
| MEDLINE
| ID: mdl-15340212
ABSTRACT
(-)-Methyl 7 beta-hydroxykaurenoate (3) and its 4-demethyl acetate (-)-4 were both synthesized via methods that contained radical cyclization and intramolecular Diels-Alder reactions as key steps. Both compounds displayed potent neuroprotective activity against N-methyl-D-aspartate toxicity in cultured cortical neurons.