1.
Sci Total Environ
; 101(1-2): 101-9, 1991 Jan 01.
Article
in English
| MEDLINE
| ID: mdl-2057758
ABSTRACT
This paper describes the use of an interactive simulation system (SONCHES) as a model and databank system. The basic model is a physiologically based toxicokinetic model (partition coefficient concept). This model takes circulation times into consideration and includes a metabolic subsystem with spot urine output. Data libraries related to the physiology of mammals, chemical substances, the external environment (exposure, physical activity, skin uptake, water intake) and real experiments allow various simulation experiments (scenarios). Scenario service and result post processing can be used to compare real experiment and simulated data (data-gathering and interpretation).