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Clin Radiol ; 70(6): 595-603, 2015 Jun.
Article in English | MEDLINE | ID: mdl-25791202

ABSTRACT

AIM: To evaluate a combined protocol for simultaneous cardiac MRI (CMR) and contrast-enhanced (CE) whole-body MR angiography (WB-MRA) techniques within a single examination. MATERIALS AND METHODS: Asymptomatic volunteers (n = 48) with low-moderate risk of cardiovascular disease (CVD) were recruited. The protocol was divided into four sections: (1) CMR of left ventricle (LV) structure and function; (2) CE-MRA of the head, neck, and thorax followed by the distal lower limbs; (3) CMR LV "late gadolinium enhancement" assessment; and (4) CE-MRA of the abdomen and pelvis followed by the proximal lower limbs. Multiple observers undertook the image analysis. RESULTS: For CMR, the mean ejection fraction (EF) was 67.3 ± 4.8% and mean left ventricular mass (LVM) was 100.3 ± 22.8 g. The intra-observer repeatability for EF ranged from 2.1-4.7% and from 9-12 g for LVM. Interobserver repeatability was 8.1% for EF and 19.1 g for LVM. No LV delayed myocardial enhancement was observed. For WB-MRA, some degree of luminal narrowing or stenosis was seen at 3.6% of the vessel segments (involving n = 29 of 48 volunteers) and interobserver radiological opinion was consistent in 96.7% of 1488 vessel segments assessed. CONCLUSION: Combined assessment of WB-MRA and CMR can be undertaken within a single examination on a clinical MRI system. The associated analysis techniques are repeatable and may be suitable for larger-scale cardiovascular MRI studies.


Subject(s)
Cardiovascular Diseases/diagnosis , Heart/physiology , Magnetic Resonance Angiography/methods , Whole Body Imaging/methods , Adult , Aged , Arterial Occlusive Diseases/diagnosis , Arterial Occlusive Diseases/physiopathology , Cardiac-Gated Imaging Techniques/methods , Cardiovascular Diseases/physiopathology , Coronary Stenosis/diagnosis , Coronary Stenosis/physiopathology , Feasibility Studies , Female , Healthy Volunteers , Humans , Magnetic Resonance Imaging, Cine/methods , Male , Middle Aged , Observer Variation
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