ABSTRACT
Seventy-nine patients with endoscopically confirmed gastric ulcers received either ranitidine (37 patients) or misoprostol (42 patients) in a randomized double-blind manner. Fifty-six percent of the patients treated with ranitidine, and 38% of those treated with misoprostol presented with endoscopically healed ulcers after four weeks of treatment. After eight weeks complete healing had occurred in 86% of the patients receiving ranitidine, and 74% of those on misoprostol. These differences were not statistically significant. In smokers, ranitidine was superior to misoprostol, leading to a higher healing rate at four weeks (73% versus 20%). Thus there was no evidence that in patients with gastric ulcer misoprostol overcomes the negative effect of cigarette smoking.
Subject(s)
Alprostadil/analogs & derivatives , Ranitidine/therapeutic use , Stomach Ulcer/drug therapy , Adult , Aged , Alprostadil/administration & dosage , Alprostadil/therapeutic use , Clinical Trials as Topic , Double-Blind Method , Female , Humans , Male , Middle Aged , Misoprostol , Random Allocation , Ranitidine/administration & dosage , Smoking/adverse effectsABSTRACT
The effect of pirenzepine and cimetidine on healing, symptoms, and relapse rate of duodenal ulcer was studied in a placebo controlled double blind trial. With regard to symptoms, cimetidine (1 g daily) was superior at the beginning of therapy to a low dose of pirenzepine (75 mg daily) and to placebo. No significant differences in ulcer healing were found between the 3 treatment groups. The relapse rate after treatment with pirenzepine was lower than after treatment with cimetidine.
Subject(s)
Benzodiazepinones/therapeutic use , Cimetidine/therapeutic use , Duodenal Ulcer/drug therapy , Guanidines/therapeutic use , Piperazines/therapeutic use , Adult , Aged , Clinical Trials as Topic , Duodenal Ulcer/prevention & control , Female , Humans , Male , Middle Aged , Pirenzepine , RecurrenceABSTRACT
The effect of pirenzepine and cimetidine on healing, symptoms and relapse rate of duodenal ulcer was studied in a placebo-controlled double-blind trial. Cimetidine (1 g daily) was superior at the beginning of therapy to a low dose of pirenzepine (75 mg daily) and placebo with regard to symptoms. No significant differences in ulcer healing were found between the 3 groups of treatment. The relapse rate after treatment with pirenzepine was lower than after treatment with cimetidine.
Subject(s)
Anti-Ulcer Agents/therapeutic use , Benzodiazepinones/therapeutic use , Cimetidine/therapeutic use , Duodenal Ulcer/drug therapy , Guanidines/therapeutic use , Adult , Anti-Ulcer Agents/adverse effects , Benzodiazepinones/adverse effects , Cimetidine/adverse effects , Clinical Trials as Topic , Double-Blind Method , Female , Humans , Male , Middle Aged , Pirenzepine , RecurrenceABSTRACT
In a controlled double-blind randomized study Thalamonal and Valium were compared in 498 esophago-gastro-duodenoscopies. Both drugs were injected intravenously immediately before the procedure. Satisfactory sedation which made additional injection of the drug during the endoscopy superfluous could be achieved in 66% of the patients with Thalamonal and in 52% with Valium respectively. The difference between the two preparations is statistically significant (p less than 0,005). In 95 patients catamnestic studies were performed in order to evaluate second episodes of fatigue after the endoscopy. A good effect of the preparation during endoscopy and a lack of second attacks of sedation following discharge was observed only in 23% of the patients after Thalamonal and in 21% of the patients after Valium injection, respectively. Therfore a good premedication was achieved in only one fifth of the patients receiving one of the two drugs.
Subject(s)
Diazepam , Droperidol , Endoscopy , Fentanyl , Neuroleptanalgesia , Premedication , Double-Blind Method , Duodenal Diseases/diagnosis , Esophagoscopy , Evaluation Studies as Topic , Gastroscopy , Humans , Injections, Intravenous , Middle AgedABSTRACT
Patients' acceptance of upper fiberpanendoscopy was significantly (p less than 0.001) better when topical anesthesia with oxybuprocaine was performed with a spray than with a lozenge.
Subject(s)
Anesthesia, Local , Anesthetics, Local/administration & dosage , Endoscopy/methods , Premedication , Administration, Oral , Aerosols , Clinical Trials as Topic , Fiber Optic Technology , Humans , TabletsABSTRACT
A double-blind randomized controlled study with pirenzepine (75 mg/day), cimetidine (1 g/day) and placebo was performed in 50 consecutive out-patients with duodenal ulcer. The patients also received an antacid containing aluminium hydroxide. Pirenzepine, cimetidine and placebo had similar effects on the 4-week healing rate. Dryness of the mouth was more frequent with pirenzepine than with the other two types of treatment. The incidence of other side effects did not differ in the three groups. A tendency towards more rapid disappearance of subjective symptoms in the patients treated with pirenzepine was not statistically significant. In conclusion, pirenzepine and cimetidine were not superior to placebo in the treatment of duodenal ulcer.
