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A novel nuclear export inhibitor JBIR-02, a new piericidin discovered from Streptomyces sp. ML55.
Ueda, Jun-Ya; Togashi, Takushi; Matukura, Susumu; Nagai, Aya; Nakashima, Takuji; Komaki, Hisayuki; Anzai, Kozue; Harayama, Shigeaki; Doi, Takayuki; Takahashi, Takashi; Natsume, Tohru; Kisu, Yasutomo; Goshima, Naoki; Nomura, Nobuo; Takagi, Motoki; Shin-Ya, Kazuo.
J Antibiot (Tokyo) ; 60(7): 459-62, 2007 Jul.
Article in English | MEDLINE | ID: mdl-17721005

ABSTRACT

A new member of the piericidin family, JBIR-02, was isolated from mycelium of Streptomyces sp. ML55 together with two known piericidin derivatives, piericidin A(1) and IT-143-B. The structure was determined on the basis of spectroscopic data. JBIR-02 inhibited nuclear export of beta-arrestin in HeLa cells at the concentration of 20 microM.


Subject(s)
Active Transport, Cell Nucleus/drug effects , Anti-Bacterial Agents/biosynthesis , Anti-Bacterial Agents/pharmacology , Pyridines/chemistry , Pyridines/pharmacology , Pyridones/pharmacology , Streptomyces , HeLa Cells/drug effects , Humans , Spectrum Analysis
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