Cardiovascular reflex tests in patients with systemic lupus erythematosus: clinical performance and utility.

Background This review summarizes current knowledge about cardiovascular reflex tests (CVRTs) and other selected autonomic nervous system (ANS) assessment tests in systemic lupus erythematosus (SLE) patients and assesses their clinical utility in this group of patients. Methods The PubMed database was searched for terms associated with CVRTs and SLE. Only papers available in full text and published in English were considered. Ultimately, 13 were selected and analyzed. Results In most of the studies CVRTs results were reported more likely to be abnormal in patients with SLE when compared with controls. The reported prevalence of ANS dysfunction in SLE, diagnosed using CVRTs, ranged from 23.5% to 82.7% of patients, likely because of different definitions of ANS dysfunction, variability in methods of performing CVRTs, and potential confounding factors. In general CVRTs results did not correlate with SLE activity or disease duration, but some CVRTs results correlated with some peptides associated with ANS function, including neuropeptide Y and vasoactive intestinal peptide. Conclusion Patients with SLE generally have abnormal or borderline results of CVRTs, which indicate prevalent abnormalities of the ANS in SLE. Performance of CVRTs requires good standardization of test conditions and familiarity with the proper administration and interpretation of these tests.

Heart rate variability in patients with systemic lupus erythematosus: a systematic review and methodological considerations.

Aim The aim of this review was to summarize current knowledge about the scientific findings and potential clinical utility of heart rate variability measures in patients with systemic lupus erythematosus. Methods PubMed, Embase and Scopus databases were searched for the terms associated with systemic lupus erythematosus and heart rate variability, including controlled vocabulary, when appropriate. Articles published in English and available in full text were considered. Finally, 11 publications were selected, according to the systematic review protocol and were analyzed. Results In general, heart rate variability, measured in the time and frequency domains, was reported to be decreased in patients with systemic lupus erythematosus compared with controls. In some systemic lupus erythematosus studies, heart rate variability was found to correlate with inflammatory markers and albumin levels. A novel heart rate variability measure, heart rate turbulence onset, was shown to be increased, while heart rate turbulence slope was decreased in systemic lupus erythematosus patients. Reports of associations of changes in heart rate variability parameters with increasing systemic lupus erythematosus activity were inconsistent, showing decreasing heart rate variability or no relationship. However, the low/high frequency ratio was, in some studies, reported to increase with increasing disease activity or to be inversely correlated with albumin levels. Conclusions Patients with systemic lupus erythematosus have abnormal heart rate variability, which reflects cardiac autonomic dysfunction and may be related to inflammatory cytokines but not necessarily to disease activity. Thus measurement of heart rate variability could be a useful clinical tool for monitoring autonomic dysfunction in systemic lupus erythematosus, and may potentially provide prognostic information.

Nutritional state of Polish prepubertal children assessed by population-specific and international standards.

OBJECTIVE: To assess the frequency of obesity, overweight and underweight (thinness) in Polish 7-9-year-old children using a population specific definition as compared to the French, US and IOTF references based on body mass index (BMI). DESIGN: Height and weight were measured and BMI was calculated in a randomly selected representative sample of 7-9-year-old Polish children (N = 2916; 1445 girls; 1471 boys) to define their nutritional status. Overweight (including obesity) was estimated according to four and underweight (thinness) according to three definitions Polish national references; French references; United States references and International Obesity Task Force references. RESULTS: According to Polish, French, U.S. and IOTF references overweight (including obesity) was found in 12.1, 14.3, 20.7 and 15.4% of children, respectively; 3.5, 9.4 and 3.6% of children were obese according to national, U.S. and IOTF references, respectively while underweight (thinness) was present in 6.9, 2.6 and 4.2% of children according to Polish, French and U.S. references, respectively. A trend of decreasing overweight and increasing underweight through age classes was observed. CONCLUSION: The rates of underweight (thinness), overweight and obesity in Polish 7-9-year-old children calculated according to the national, French, U.S. and IOTF references were significantly different. Therefore even if the IOTF reference is considered superior for international epidemiological studies, population specific standards should probably coexist for clinical practice.

Even young patients with no alarm symptoms should undergo endoscopy for earlier diagnosis of gastric cancer.

BACKGROUND AND STUDY AIMS: There has been a tendency in recent years to omit endoscopy in dyspeptic patients younger than 45 years with no so-called "alarm symptoms." This study was conducted to test whether this policy might lead to an increased rate of delayed diagnosis of gastric cancer, especially in a population with a high prevalence of the disease. PATIENTS AND METHODS: The study included 860 patients (465 women, 395 men; median age 44) referred for the first time for upper gastrointestinal endoscopy because of suspected upper gastrointestinal pathology, to a secondary referral center between 1983 and 1993. Symptoms were assessed using a special questionnaire prior to endoscopy. The endoscopic diagnosis was always confirmed by histology. RESULTS: Gastric cancer was found in 83 patients (12 early cancers, 71 advanced). Patients with cancer were predominantly male (68 %, compared with 44 % in the no-cancer group; P < 0.001), and significantly older (median age 56, 44 and 42 years for advanced, early cancer, and no cancer, respectively; P < 0.001). As many as 24 % of patients with cancer were aged under 45 years. Symptoms occurring more frequently in the gastric cancer group compared with the no-cancer group were weight loss (11 % vs. 0.1 %; P < 0.001), gastrointestinal bleeding (18 % vs. 8 %; P < 0.001), anorexia (43 % vs. 25 %; P < 0.001), and fatigue (53 % vs. 30 %; P < 0.001). In 27 % of cancer patients none of the above symptoms was observed. No statistical difference was seen for pain, nausea, vomiting, and other symptoms. The mean symptom score (1 point for one symptom) was higher in patients with cancer compared with those without (3.1 vs. 2.4; P < 0.001). The duration score (1 to 4 points for durations of less than 6, less than 12, less than 24, and more than 24 months) was lower (1.3 vs. 1.8; P < 0.001) in cancer patients. In three-quarters of cancer patients the duration of symptoms was shorter than 6 months. CONCLUSIONS: Symptoms suggesting gastric cancer are gastrointestinal bleeding, weight loss, and to a lesser degree anorexia and fatigue. Gastric cancer patients show a greater intensity but shorter duration of symptoms than patients with no cancer. Age and alarm symptoms cannot determine the need for upper gastrointestinal endoscopy, at least in areas of high prevalence of gastric cancer.

[Fine-needle aspiration biopsy in the diagnosis of nodular thyroid disease in children]. / Biopsja aspiracyjna cienkoiglowa w diagnostyce choroby guzkowej tarczycy u dzieci.

BACKGROUND: Fine-needle aspiration biopsy (FNAB) is a standard diagnostic procedure for adult patients with thyroid nodules. However, it is still controversial whether in pediatric patients thyroid nodules should be aspirated or excised. The aim of the study was to determine the usefulness of FNAB in clinical evaluation and follow up of children with nodular thyroid disease. MATERIAL AND METHODS: The study group comprised 36 children (33 girls and 3 boys) aged from 10 to 18 years (mean age 13.6 years) with nodular goiter. All children were in euthyreosis and their goiter size ranged from IAo to IIIo according to WHO criteria. In all the patients FNAB was performed and in 13 it was repeated after 4-8 months. RESULTS: Cytology of the first FNAB in 25 (69.5%) children showed colloid nodules, in 3 (8.3%)--carcinoma papillare, in 3 (8.3%)--neoplasma folliculare (NF), in 4 (11.1%)--Hashimoto thyroiditis and in 1 (2.8%)--thyroiditis granulosa de Quervaine. In one girl, in whom colloid nodule was cytologically diagnosed, FNAB was repeated after 4 months because of the nodule growth and change in the USG structure revealed papillary carcinoma. In one boy NF diagnosed in first biopsy was not confirmed in the second one (patient's parents refused the consecutive biopsy). All children with malignant or suspicious cytology and three with goiter size IIIo were operated and postoperative histopathological examination was performed. All colloid nodules were confirmed histopathologically, but in one patient with a large colloid goiter follicular adenoma was found. In two children with NF in cytology--follicular adenoma was found and in three patients with papillary carcinoma in FNAB--the diagnosis was confirmed. In all children in whom thyroid nodules did not expand in the volume, did not change their structure or regressed on USG, repeated FNAB confirmed the first diagnosis. CONCLUSIONS: 1. FNAB is useful in diagnosis and management of nodular thyroid disease in children. 2. Cytology of repeated biopsies of the nodules that decreased or did not increase in size confirms the primary diagnosis. 3. All children with thyroid nodules have to be carefully followed-up, and in case of nodule growth and/or change of the USG picture, repeated FNAB is necessary.