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Article in Russian | MEDLINE | ID: mdl-19715204

ABSTRACT

AIM: To study the influence of Solcotichovac vaccine on formation of neutrophil extracellular traps. MATERIALS AND METHODS: Solcotrichovac vaccine administered in various doses was used in order to assess the formation of neutrophil extracellular traps in peripheral blood of women of childbearing age. RESULTS: Therapeutic dose of Solcotrichovac stimulated the most prominent formation of neutrophil extracellular traps. CONCLUSION: Solcotrichovac vaccine stimulated non-specific arm of mucosal immunity due to formation of neutrophil extracellular traps and it is probable that this mechanism explains the effect of this vaccine.


Subject(s)
Bacterial Vaccines/administration & dosage , Bacterial Vaccines/immunology , Neutrophils/immunology , Adult , Dose-Response Relationship, Immunologic , Female , Humans , Immunity, Innate , Mucous Membrane/immunology , Neutrophils/ultrastructure , Vagina/immunology
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