[The nature of the pancreatic hormone secretion and of the metabolic indices during the acute and chronic administration of peroral hypoglycemic preparations]. / Izuchenie kharaktera sekretsii gormonov podzheludochnoi zhelezy i nekotorykh metabolicheskikh pokazatelei pri ostrom i khronicheskom vvedenii peroral'nykh sakharoponizhaiushchikh preparatov.

A comparative study of the effect of acute and chronic administration of sulfanilureal sugar lowering drugs (glipizide and glibenclamide) on the secretion of the pancreatic hormones, indices of microcirculation, the level of triglycerides and nonesterified fatty acids was conducted. Patients with primary detected diabetes mellitus with normal body mass and obesity of I-III degrees were investigated. The principal differences in insulinotropic action of sugar lowering drugs in various groups of patients and significant differences in the mechanism of their hypoglycemic action at varying time of treatment indicate the necessity of a strictly differentiated approach to subscription of these drugs for patients with primary detected diabetes mellitus.

[Functional reserves of myocardial perfusion in patients with chronic ischemic heart disease with varying degrees of damage of the coronary arteries]. / Funktsional'nye rezervy perfuzii miokarda u bol'nykh khronicheskoi ishemicheskoi bolezn'iu serdtsa s razlichnoi stepen'iu porazheniia koronarnykh arterii.

A comparative study of data provided by coronaro-angiography and myocardial perfusion scintigraphy (resting and exercise tests), and clinical/electrocardiographic results of the exercise test in 102 chronic coronary patients demonstrated that non-invasive myocardial perfusion 201Tl scintigraphy combined with threshold bicycle-ergometric exercise adds considerably to the clinico-electrocardiographic assessment of the exercise test and thus helps to detect myocardial blood supply (perfusion) disorders in some of coronary patients with doubtful or negative test results. Reduced functional reserves of myocardial blood supply, as reflected in deficient perfusion at the peak of threshold exercise, are seen in all coronary patients with angiographically intact coronary arteries and in most patients with both the so-called "functionally-insignificant" and marked coronary arterial stenosis (94.7 and 88.3%, respectively).

Diagnostic value of pulsed Doppler echocardiography in combined heart defects.

26 patients with combined heart defects were examined by means of ultrasound methods (one-dimensional, two-dimensional and Doppler echocardiography). The results were compared with the results of clinical and roentgenological examinations. Taking into account literary data on high sensitivity and specificity of Doppler echocardiography, its informative value was assessed in cases when affection of two or more valves results in a balancing of haemodynamic changes. It was documented that pulsed Doppler EchoCG makes possible to assess the character and the direction of blood flow in different phases of the cardiac cycle in the heart cavities and the great vessels, and thereby provides additional information on the involvement of the valvular apparatus and on the state of haemodynamics. The sensitivity of this method is particularly high in the detection of regurgitant flow.

[Interrelation of the state of perfusion and the coronary vascular bed in patients with chronic ischemic heart disease]. / Vzaimosviaz' sostoianiia perfuzii i koronarnogo sosudistogo rusla u bol'nykh khronicheskoi ishemicheskoi bolezn'iu serdtsa.

Coronary angiographic and scintigraphic (using 201Tl) studies in 139 patients with verified diagnosis of chronic coronary heart disease demonstrated high sensitivity (85.6%) of myocardial perfusion scintigraphy with respect to detecting disorders of myocardial blood supply due to the stenosis of major coronary arteries and microcirculation disorders. False negative scintigraphic results in the screening for perfusion defects are commonly due to the shortcomings of semiquantitative assessment of the scintigrams.

[Intravenous isoproterenol administration for diagnosing ischemic heart disease in women: a comparison with the data from bicycle ergometry and selective coronary angiography]. / Vnutrivennoe vvedenie izoproterenola dlia diagnostiki ishemicheskoi bolezni serdtsa u zhenshchin: sravnenie s dannymi veloérgometrii i selektivnoi koronarografii.

The significance of the test with intravenous injection of isoproterenol in the diagnosis of coronary heart disease (CHD) was evaluated in comparison with the clinical, bicycle ergometry and selective coronarography data obtained in 65 women. Twenty-four patients presented with stenosing coronary atherosclerosis and 41 patients had normal coronary arteries. On the use of the electrocardiographic signs of myocardial ischemia the sensitivity of the isoproterenol test in the diagnosis of hemodynamically appreciable coronary atherosclerosis was 74%, the specificity 78%. The sensitivity and specificity of bicycle ergometry were 66 and 90%, respectively.

[The bicycle ergometry test in the diagnosis of ischemic heart disease in women (a comparison with selective coronary angiographic data)]. / Veloérgometricheskaia proba v diagnostike ischemicheskoi bolezni serdtsa u zhenshchin (sravnenie s dannymi selektivnoi koronaroangiografii).

The bicycle ergometric test and selective coronary angiography were performed in 105 women with 39 of them presenting stenosis of the coronary arteries. Judging by the electrocardiographic criteria, the test sensitivity was 68%, its specificity being 90%. Normalization of the ECG at the height of the submaximal exercise in the presence of the baseline changes in the ST-T interval may serve as an additional criterion of the absence of coronary artery stenosis. When the test was evaluated by clinical and electrocardiographic criteria, its specificity decreased.

[Roentgenologic evaluation of myocardial contractility in heart valve diseases]. / Rentgenologicheskaia otsenka sokratitel'noi funktsii miokarda pri klapannykh porokakh serdtsa.

The authors compare the roentgenological findings with the parameters of contractility obtained during heart catheterization in 49 patients with mitral valvular disease and aortal valvular disease. The parameters are shown to be correlated with regard to the nature of valvular damage, characteristics of the impairment of the intracardiac hemodynamics and myocardial contractile function. Certain tendencies of this dependence are tabulated.

[The dipyridamole test in the diagnosis of ischemic heart disease in women]. / Proba s dipiridamolom v diagnostike ishemicheskoi bolezni serdtsa u zhenshchin.

Bicycle ergometry and the dipyridamol test were performed in 25 females with coronary artery stenosis and 42 with unchanged coronary arteries (according to the coronarography data). The sensitivity of the dipyridamol test was 80% at its specificity was 78% according to the electrocardiographic data that correlated well with those of bicycle ergometry. The dipyridamol test can be used for examining females with suspected coronary heart disease.