1.
J Org Chem
; 84(3): 1448-1460, 2019 Feb 01.
Article
in English
| MEDLINE
| ID: mdl-30618255
ABSTRACT
The electrochemically induced cross-dehydrogenative C-O coupling of ß-diketones and ß-ketoesters (C-H reagents) with carboxylic acids (O-H reagents) was developed. An important feature of this reaction lies in the selective formation of intermolecular C-O coupling products in high yields, up to 92%, using DMSO as a solvent with a broad substrate scope in an undivided cell equipped with carbon and platinum electrodes at high current density. Electric current acts as a stoichiometric oxidant.