ABSTRACT
The therapeutic effect of pristine C60 fullerene aqueous colloid solution (C60FAS) on the functioning of the rat soleus muscle at ischemic injury depending on the time of the general pathogenesis of muscular system and method of administration C60FAS in vivo was investigated. It was found that intravenous administration of C60FAS is the optimal for correction of speed macroparameters of contraction for ischemic muscle damage. At the same time, intramuscular administration of C60FAS shows pronounced protective effect in movements associated with the generation of maximum force responses or prolonged contractions, which increase the muscle fatigue level. Analysis of content concentration of creatine phosphokinase and lactate dehydrogenase enzymes in the blood of experimental animals indicates directly that C60FAS may be a promising therapeutic agent for the prevention and correction of ischemic-damaged skeletal muscle function.
ABSTRACT
The formation of connective tissue changes in the spinal canal of rats, caused by the method of intervertebral disc ruptures, in association with a mixture of epidural injection of longidaza and diprospan has been researched. Simultaneous injection of hialuronidase and betamethasone in composition of diprospan and longidaza, revealed a high synergistic effect and anti-fibrotic activity. Combined antifibrosis action of these two drugs is stronger than the sum of the actions of the two drugs in their separate use. Reducion of the maximum thickness of the fibrous layer was 49%, compared with the reference value and reduction of the total area of the fibrous formation was 46%. In our opinion, due to anti-inflammatory effects and the ability to reduce epidural scar adhesion, this complex is promising for its therapeutic use in treatment of spinal epidural fibrosis.
Subject(s)
Anti-Inflammatory Agents/pharmacology , Betamethasone/analogs & derivatives , Hyaluronoglucosaminidase/pharmacology , Intervertebral Disc Degeneration/drug therapy , Intervertebral Disc Displacement/drug therapy , Intervertebral Disc/drug effects , Polymers/pharmacology , Rupture/drug therapy , Animals , Betamethasone/pharmacology , Disease Models, Animal , Drug Combinations , Drug Synergism , Fibrosis/prevention & control , Intervertebral Disc/pathology , Intervertebral Disc/physiopathology , Intervertebral Disc Degeneration/pathology , Intervertebral Disc Degeneration/physiopathology , Intervertebral Disc Displacement/pathology , Intervertebral Disc Displacement/physiopathology , Rats , Rats, Wistar , Rupture/pathology , Rupture/physiopathology , Treatment OutcomeABSTRACT
The data regarding the analysis of the physiological and biochemical mechanisms of muscle fatigue and ways to prevent it are summarized. The effect of the most common endogenous and exogenous antioxidants in the biochemical processes in muscle fatigue was analyzed. It is shown that biocompatible, non-toxic water-soluble C(60) fullerenes, which possess powerful antioxidative properties, promise great prospects in the correction of skeletal muscle fatigue caused by the destructive action of free radicals.