[Effect of verapamil on arterial pressure and various parameters of heart contractile function in rabbits with prerenal artery hypertension when administered at various times of day]. / Vliianie verapamila na arterial'noe davlenie i nekotorye pokazateli sokratitel'noi funktsii serdtsa u krolikov s renoprivnoi arterial'noi gipertenziei pri ego vvedenii vraznoe vremia sutok.

The dynamics of arterial blood pressure and some data of cardiac contractility in rabbits with vasorenal hypertension were investigated in 4 seasons of the year. Simultaneously, the effects of verapamil on the said data were studied in rabbits with vasorenal hypertension (verapamil was administered at 12 and 18 h during last 2 weeks of experiment). In different seasons the definite differences in therapeutic effect of verapamil depending on the time of its administration were revealed.

[Seasonal changes in blood pressure and certain indicators of cardiac contractile function in intact rabbits]. / Sezonnye izmeneniia urovnia arterial'nogo davleniia i nekotorykh pokazatelei sokratitel'noi funktsii serdtsa u intaktnykh krolikov.

Some data of intact rabbits' cardiovascular system (arterial blood pressure, data of real and maximum function of heart ventricles) were investigated in different seasons of the year. It was revealed, that in winter the cardiovascular system functions with definite degree of overstrain, and in summer these data are on the lower level of the norm. Correlative analysis showed that in summer the degree of synchronization of the function of cardiovascular system drops and this can open wide possibilities for it's adaptation to variable conditions.

[Effect of altitude hypoxia on ultrastructure of the left ventricle of rabbit heart and the response of the myocardium to acute verapamil administration at different altitudes]. / Vliianie gornoi gipoksii na sostoianie ul'trastruktury levogo zheludochka serdtsa krolikov i reaktsiia miokarda na ostroe vvedenie verapamila na razlichnykh vysotakh.

It was shown in experiments on intact male rabbits that moderate-altitude hypoxia causes over-stress of the cardiomyocyte energy-producing apparatus in unadapted animals. Acute infusion of verapamil leads to a high mortality rate among these animals, whereas among aborigines of moderate and low altitudes as well as among animals living in the planes mortality in acute verapamil infusion does not exceed 30%.