Subject(s)
Aneurysm, Infected/microbiology , Candidiasis , Endocarditis/microbiology , Heart Valve Prosthesis/adverse effects , Popliteal Artery/microbiology , Prosthesis-Related Infections , Aneurysm, Infected/surgery , Antifungal Agents/therapeutic use , Aortic Valve Stenosis/congenital , Aortic Valve Stenosis/surgery , Candidiasis/drug therapy , Humans , Male , Middle Aged , ReoperationABSTRACT
Subacute meningitis caused by Candida albicans was confirmed by culture and immunoserologically in a 19-year-old girl. Combined administration of amphotericin B and flucytosine only slowly affected the course of the disease despite impressive improvement in clinical symptoms. Pleocytosis (1000/mm3) in cerebrospinal fluid persisted. Falling Candida antibody titre in serum and CSF, however, pointed to an improvement in the acute infection. Treatment had to be discontinued after 42 days because of side-effects such as rigor, fever and polyuria with low concentration. Under serial clinical observations with occasional CSF punctures complete cure occurred with normal CSF findings. There was an additional and unusual neurological-otological condition of intermittent inner-ear deafness, left more than right, before treatment. Recording of early auditory evoked potentials pointed to an involvement of the cranial nerves as part of the inflammatory process.
