Mexican population sub-analysis of the lixilan clinical program with the fixed ratio combination of insulin glargine and lixisenatide (iGlarLixi).

AIM: To evaluate the efficacy and safety of iGlarLixi in Mexican patients with type 2 diabetes who participated in the LixiLan clinical trials and compare results with the rest of the patients. METHODS: Data was collected for Mexican patients who participated in either of three studies: phase 2 trial LixiLan-POC, that compared iGlarLixi vs insulin glargine (iGlar) on inadequately controlled patients with metformin; phase 3 trial LixiLan-O, comparing iGlarLixi vs iGlar and lixisenatide on inadequately controlled patients with oral antidiabetic agents; and finally the phase 3 trial LixiLan-L, comparing iGlarLixi vs iGlar on inadequately controlled patients with basal insulin. The primary endpoint was the change in HbA1c from baseline to end of treatment. RESULTS: In the Mexican population, treatment with iGlarLixi significantly improved HbA1c compared with each component alone achieving an average of 6.5%; (6.17%, 6.63% and 6.73% for the LixiLan-POC, O and L studies respectively) and an average HbA1c reduction from baseline of 1.6%, for the three studies at end of treatment period. CONCLUSION: The efficacy and safety profile of iGlarLixi demonstrate a fair or better composite endpoint of HbA1c without hypoglycemia and no weight gain compared to overall trial population, which could help improve Mexican patients' outcomes.

Food partitioning and community organization in a mountain lizard guild of Northern Mexico.

Food niche relationships among four sympatric Sceloporus species were studied in the Sierra Madre Occidental, N.E. Mexico. Although some very high food-niche overlap values were observed, this does not prove that interspecific competition is currently important in organizing this lizard assemblage. Moreover, explaining habitat segregation among the coexisting species as an ecological result of interspecific competitive pressure is unlikely: the overall ecology and behaviour of these species is too much dependent on their microhabitat or substrate specialization to allow such an exclusive interpretation. Thus, this community is probably not mainly organized by species interactions but rather through the specific ecological needs of each species.