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2.
QJM ; 101(11): 889-98, 2008 Nov.
Article in English | MEDLINE | ID: mdl-18805904

ABSTRACT

BACKGROUND: Bacteraemia is a significant cause of mortality and healthcare expenditure. Evidence suggests that consultation by an infection specialist may improve outcomes. AIM: To review the characteristics and outcomes of patients seen by a newly implemented bacteraemia service. METHODS: Retrospective review of data collected at time of consultation. Economic analyses and benchmarking of outcomes were also performed. RESULTS: One hundred and fifty-one patients were seen by the service over an 18-month period. Staphylococcus aureus was the most common isolate and central venous lines the most common source. Antibiotics were changed and additional investigations suggested in 62% and 61% of patients, respectively. The 30-day mortality was 19%. Implementation and delivery of the service over the 18-month study period cost pound 22,663 (pound 15,109 per year). The cost per change in antibiotic prescription was pound 244. The cost per 'near-miss' detected was pound 1193. Overall mortality was no higher and possibly lower than in published studies. CONCLUSION: We believe that this model of care may be suitable for the management of patients with bacteraemia. A study assessing the cost-effectiveness of this approach is required.


Subject(s)
Anti-Bacterial Agents/therapeutic use , Bacteremia/drug therapy , Delivery of Health Care/economics , Program Development , Aged , Anti-Bacterial Agents/economics , Bacteremia/mortality , Cost-Benefit Analysis , England , Female , Humans , Male , Middle Aged , Pilot Projects
3.
Epidemiol Infect ; 130(2): 187-92, 2003 Apr.
Article in English | MEDLINE | ID: mdl-12729186

ABSTRACT

On 18 February 2002, the Communicable Disease Unit was notified by the local Public Health Service Laboratory of a child with a positive skin swab for Pseudomonas aeruginosa. This child had attended the local swimming pool and played on an inflatable, subsequently presenting to a Primary Care Nurse Practitioner with folliculitis. A total of 35 cases was identified during the outbreak. This paper describes a case-control study and microbiological sampling of the cases, the suspected inflatable and a survey of 10 swimming pool inflatables in the local area. The odds ratio for developing folliculitis following use of the inflatable was 12 (95% CI 1.05-136.80). The strain of P. aeruginosa found on the inflatable was identical to that obtained from skin swabs of cases. Nine of 10 (90%) of the inflatables sampled were colonized by P. aeruginosa. Attention should be given to the problem of routine decontamination of swimming pool inflatables. P. aeruginosa folliculitis needs to be considered in the differential diagnosis of skin rashes in children, especially in Primary Care.


Subject(s)
Folliculitis/epidemiology , Pseudomonas Infections/epidemiology , Pseudomonas aeruginosa/isolation & purification , Water Microbiology , Case-Control Studies , Disease Outbreaks , Disinfection , Folliculitis/etiology , Humans , Pseudomonas Infections/etiology , Swimming Pools
5.
Epidemiol Infect ; 113(1): 21-9, 1994 Aug.
Article in English | MEDLINE | ID: mdl-8062876

ABSTRACT

A family outbreak of Salmonella enteritidis PT4 infection is described in which home-made ice cream was identified as the vehicle of infection. The ice cream contained approximately 10(5) S. enteritidis PT4 organisms per gm and was probably contaminated by an infected shell egg containing between 10(5)-10(8) organisms. The continued relevance of the Chief Medical Officer's warning on the use of raw shell eggs is highlighted. Home-made ice cream using the same recipe as ice cream that had been incriminated as the cause of the family outbreak of S. enteritidis PT4 infection was used to study the growth of the organism that might have occurred in the 3-4 h it took to prepare the product. When the inoculum was in the stationary phase, as it would be from shell or other cross contamination, there was a lag phase of 3 h before growth occurred at room temperature. Even when actively multiplying organisms were introduced, as may be found in an infected egg, there was less than 3 log(10) increase in the salmonella count in 4 h at room temperature. It was, therefore, given the high S. enteritidis count, unlikely that the ice cream was cross-contaminated. By contrast, raspberry sorbet at pH 3.73 proved to be lethal to a large inoculum of S. enteritidis and may be a relatively safe raw egg containing product.


Subject(s)
Eggs/microbiology , Food Microbiology , Ice Cream/microbiology , Salmonella Food Poisoning/etiology , Salmonella enteritidis/growth & development , Animals , Colony Count, Microbial , Diarrhea/epidemiology , Diarrhea/etiology , Disease Outbreaks , Feces/microbiology , Female , Humans , Hydrogen-Ion Concentration , London/epidemiology , Pregnancy , Pregnancy Complications, Infectious/epidemiology , Pregnancy Complications, Infectious/etiology , Salmonella Food Poisoning/epidemiology , Salmonella enteritidis/isolation & purification , Temperature
6.
Epidemiol Infect ; 103(3): 415-23, 1989 Dec.
Article in English | MEDLINE | ID: mdl-2691262

ABSTRACT

Two small flocks of egg-laying hens, naturally infected with Salmonella enteritidis, were housed in individual cages so that their eggs could be identified. During a longitudinal study where the contents of 1,119 eggs were examined, 11 were positive for S. enteritidis. One isolate was phage type (PT) 33 the others were PT4. The production of infected eggs was clustered though intermittent. The positive eggs, which were produced by 10 of the 35 hens, were all found to contain fewer than 10 salmonellas. Some birds were also apparently carrying S. hadar PT14 as this organism was isolated from the contents of six cracked eggs.


Subject(s)
Chickens/microbiology , Eggs , Food Contamination/statistics & numerical data , Poultry Diseases/microbiology , Salmonella Infections, Animal/microbiology , Salmonella enteritidis/classification , Animals , Bacteriophage Typing , Disinfection , Egg Shell , Female , Incidence , Longitudinal Studies
7.
BMJ ; 299(6702): 771-3, 1989 Sep 23.
Article in English | MEDLINE | ID: mdl-2508916

ABSTRACT

OBJECTIVE: To determine the source of indigenous sporadic infection with Salmonella enteritidis phage type 4. DESIGN: Case-control study of primary sporadic cases identified by the Public Health Laboratory Service between 1 August and 30 September 1988. SETTING: PHLS Communicable Disease Surveillance Centre, Division of Enteric Pathogens, 11 PHLS laboratories, and 42 local authority environmental health departments in England. SUBJECTS: 232 Patients (cases) with confirmed primary sporadic infection, for 160 of whom (88 female) (median age 30 years, age range 4 months to 85 years) data were obtained by questionnaire about consumption of fresh eggs, egg products, precooked chicken, and minced meat in the three days and one week before onset of the symptoms. Up to three controls, matched for neighbourhood, age, and sex (if aged greater than 11 years), were asked the same questions for the same calendar period. MAIN OUTCOME MEASURE: Association of primary sporadic infection with consumption of suspected food items. RESULTS: Illness due to S enteritidis phage type 4 was significantly associated with consumption of raw shell egg products (homemade mayonnaise, ice cream, and milk drinks containing eggs) (matched p = 0.02) and shop bought sandwiches containing mayonnaise (matched p = 0.00004) or eggs (matched p = 0.02). Illness was also significantly associated with eating lightly cooked eggs (unmatched p = 0.02), but not soft boiled eggs, and precooked hot chicken (matched p = 0.006). Reported consumption of eggs was not appreciably different between cases and controls before or after the median date of interview. CONCLUSIONS: Fresh shell eggs, egg products, and precooked hot chicken are vehicles of S enteritidis phage type 4 infection in indigenous sporadic cases. Public health education and reduction in contamination of eggs and infection of poultry with S enteritidis are needed to reduce the incidence of human infection.


Subject(s)
Eggs/adverse effects , Food Contamination , Poultry Products/adverse effects , Salmonella Food Poisoning/etiology , Salmonella Phages , Adolescent , Adult , Aged , Aged, 80 and over , Case-Control Studies , Child , Child, Preschool , Disease Reservoirs , Humans , Infant , Middle Aged , Salmonella enteritidis , Time Factors
8.
Epidemiol Infect ; 103(1): 47-52, 1989 Aug.
Article in English | MEDLINE | ID: mdl-2673825

ABSTRACT

In 1988 there were two outbreaks of infection with Salmonella enteritidis phage type 4 in adjacent local authorities. The first affected 18 of 75 helpers and guests who attended a private function. Investigations revealed that home-made vanilla ice-cream containing uncooked eggs was the vehicle of infection and the causative organism was identified at the premises of the egg producer. The second affected 84 of 422 delegates attending a conference dinner, and 12 of 50 hotel staff at risk. A dessert made with lightly-cooked egg yolk and raw egg white was associated with infection, and the epidemic strain was cultured from the shell of an egg and an environmental sample from the producer's farm. It is of interest that one outbreak involved free-range and one battery-produced eggs, and that in one the vehicle was prepared at home and in the other in commercial premises. In neither incident was any deficiency in standards of egg production or catering practice discovered.


Subject(s)
Disease Outbreaks , Food Contamination , Salmonella Food Poisoning/epidemiology , Animals , Cohort Studies , Eggs , England , Food Microbiology , Humans , Interviews as Topic , Salmonella Food Poisoning/etiology , Salmonella enteritidis , Surveys and Questionnaires
9.
Epidemiol Infect ; 101(2): 287-94, 1988 Oct.
Article in English | MEDLINE | ID: mdl-3181312

ABSTRACT

Campylobacter organisms isolated from water samples taken weekly from ponds and land-drains in the City of Hull were compared with isolates from humans. Of 314 campylobacter organisms isolated from patients, 237 (75.5%) of the strains were identified as typical Campylobacter jejuni, whilst of 125 identified strains isolated from the water samples, 85 (68%) resembled C. jejuni in most respects but were hippurate hydrolysis negative by the Hwang and Ederer method. The ponds and land drains in the city were therefore not a source of campylobacteriosis in the people living near these water courses. The atypical C. jejuni strains isolated from the environment may be mistaken for the C. jejuni strains which cause human infection. It is therefore essential that such strains are fully identified before attributing human and animal infections to their ingestion.


Subject(s)
Campylobacter Infections/microbiology , Campylobacter/isolation & purification , Water Microbiology , Animals , Campylobacter/classification , Campylobacter/growth & development , Campylobacter fetus/classification , Campylobacter fetus/growth & development , Campylobacter fetus/isolation & purification , Colony Count, Microbial , England , Feces/microbiology , Humans , Serotyping
10.
Epidemiol Infect ; 101(2): 295-300, 1988 Oct.
Article in English | MEDLINE | ID: mdl-3181313

ABSTRACT

Three human volunteer experiments were performed in which river water expected to contain campylobacter organisms was ingested. Despite the ingestion of over 44,000 organisms in one experiment, the subject did not suffer any symptoms, nor were campylobacter organisms excreted, nor was an antibody response to the ingested strains detected. The campylobacter organisms ingested resembled Campylobacter jejuni on colonial and microscopic morphology but were hippurate negative, and were distinct from C. coli. These environmental campylobacter strains appear to be non-pathogenic, however they may be mistaken for C. jejuni or C. coli if they are not fully identified.


Subject(s)
Campylobacter Infections/microbiology , Campylobacter/pathogenicity , Water Microbiology , Adult , Campylobacter/classification , Campylobacter/isolation & purification , Colony Count, Microbial , Feces/microbiology , Fresh Water , Humans , Serotyping
16.
J Clin Pathol ; 31(1): 12-5, 1978 Jan.
Article in English | MEDLINE | ID: mdl-342544

ABSTRACT

The turbidimetric responses of a strain of Escherichia coli K12 to gentamicin and tobramycin were investigated. Both agents showed antibacterial activity below the conventionally measured minimum inhibitory concentration, but exposure to such subinhibitory concentrations of either agent generated a bacterial population which was able to grow in previously inhibitory concentrations at a rate equivalent to that of the parent culture. The increase in resistance was non-specific in that both aminoglycosides were equally affected, and was unstable on multiple passage in drug-free broth. The response to tobramycin was unaffected by the presence of an R factor conferring gentamicin resistance, but exposure of the R factor bearing strain to gentamicin caused a concomitant increase in the resistance to tobramycin, apparently by a non-specific adaptive mechanism similar to that observed with the parent strain. It is suggested that prior treatment of a gentamicin-resistant organism with gentamicin (as may occur during blind therapy) may adversely affect the subsequent response to other aminoglycosides.


Subject(s)
Anti-Bacterial Agents/pharmacology , Escherichia coli/drug effects , Gentamicins/pharmacology , Tobramycin/pharmacology , Adaptation, Physiological , Drug Resistance, Microbial , Escherichia coli/genetics , Escherichia coli/growth & development , Nephelometry and Turbidimetry , R Factors
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