Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters










Database
Language
Publication year range
1.
Eur J Immunol ; 31(8): 2357-61, 2001 Aug.
Article in English | MEDLINE | ID: mdl-11500818

ABSTRACT

Current literature indicates that elevated IL-6 serum levels are associated with diseases, disability and mortality in the elderly. In this paper, we studied the IL-6 promoter genetic variability at -174 C/G locus and its effect on IL-6 serum levels in a total of 700 people from 60 to 110 years of age, including 323 centenarians. We found that the proportion of homozygotes for the G allele at -174 locus decreases in centenarian males, but not in centenarian females. Moreover, we found that, only among males, homozygotes for the G allele at -174 locus have higher IL-6 serum levels in comparison with carriers of the C allele. On the whole, our data suggest that those individuals who are genetically predisposed to produce high levels of IL-6 during aging, i.e. -174 locus GG homozygous men, are disadvantaged for longevity.


Subject(s)
Genetic Predisposition to Disease , Interleukin-6/genetics , Longevity/genetics , Sex Characteristics , Aged , Aged, 80 and over , Alleles , DNA Mutational Analysis , Female , Gene Frequency , Homozygote , Humans , Interleukin-6/biosynthesis , Interleukin-6/blood , Life Expectancy , Longevity/immunology , Male , Middle Aged , Polymorphism, Genetic/genetics , Promoter Regions, Genetic/genetics
SELECTION OF CITATIONS
SEARCH DETAIL
...