ABSTRACT
The aim of the present study was to investigate the effect of atropine on renal tubular membranes, as we suggested in a previous work. Mongrel dogs were anesthetized and i.v. infused with isotonic NaCl solutions. Ureters were catheterized and urine samples collected every 10 minutes. Different groups of dogs received single i.v. doses of aldosterone (2 and 4 ug/kg body wt); atropine (1 ug/kg body wt); atropine prior to the low dose of aldosterone; and saline solution (1 ml). The administration of atropine prior to the low dose of aldosterone enhanced the antinatriuretic effect of the latter and furthermore produced an anticipation in time for the effect. The results obtained seem compatible with an atropine effect producing changes in the tubular membranes modifying its permeability or transport capacity.
Subject(s)
Aldosterone/pharmacology , Atropine/pharmacology , Kidney Tubules/metabolism , Sodium/metabolism , Animals , Dogs , Dose-Response Relationship, Drug , Kidney Tubules/drug effects , Kidney Tubules/physiology , Sodium/urineABSTRACT
The aim of the present study was to investigate the effect of atropine on renal tubular membranes, as we suggested in a previous work. Mongrel dogs were anesthetized and i.v. infused with isotonic NaCl solutions. Ureters were catheterized and urine samples collected every 10 minutes. Different groups of dogs received single i.v. doses of aldosterone (2 and 4 ug/kg body wt); atropine (1 ug/kg body wt); atropine prior to the low dose of aldosterone; and saline solution (1 ml). The administration of atropine prior to the low dose of aldosterone enhanced the antinatriuretic effect of the latter and furthermore produced an anticipation in time for the effect. The results obtained seem compatible with an atropine effect producing changes in the tubular membranes modifying its permeability or transport capacity.