Associations between air pollutants and blood pressure in an ethnically diverse cohort of adolescents in London, England.

Longitudinal evidence on the association between air pollution and blood pressure (BP) in adolescence is scarce. We explored this association in an ethnically diverse cohort of schoolchildren. Sex-stratified, linear random-effects modelling was used to examine how modelled residential exposure to annual average nitrogen dioxide (NO2), particulate matter (PM2.5, PM10) and ozone (O3), measures in µg/m3, associated with blood pressure. Estimates were based on 3,284 adolescents; 80% from ethnic minority groups, recruited from 51 schools, and followed up from 11-13 to 14-16 years old. Ethnic minorities were exposed to higher modelled annual average concentrations of pollution at residential postcode level than their White UK peers. A two-pollutant model (NO2 & PM2.5), adjusted for ethnicity, age, anthropometry, and pubertal status, highlighted associations with systolic, but not diastolic BP. A µg/m3 increase in NO2 was associated with a 0.30 mmHg (95% CI 0.18 to 0.40) decrease in systolic BP for girls and 0.19 mmHg (95% CI 0.07 to 0.31) decrease in systolic BP for boys. In contrast, a 1 µg/m3 increase in PM2.5 was associated with 1.34 mmHg (95% CI 0.85 to 1.82) increase in systolic BP for girls and 0.57 mmHg (95% CI 0.04 to 1.03) increase in systolic BP for boys. Associations did not vary by ethnicity, body size or socio-economic advantage. Associations were robust to adjustments for noise levels and lung function at 11-13 years. In summary, higher ambient levels of NO2 were associated with lower and PM2.5 with higher systolic BP across adolescence, with stronger associations for girls.

Age-related changes in pain sensitivity in healthy humans: A systematic review with meta-analysis.

Literature suggests that pain perception diminishes in old age. The most recent review used search strategies conducted over a decade ago and concluded that study findings were equivocal. The aim of this systematic review, with meta-analysis, was to determine age-related changes in pain sensitivity in healthy pain-free adults, children and adolescents. A search of PubMed, Science Direct, and PsycINFO identified studies that compared pain sensitivity response to noxious stimuli at different time points in the lifespan of healthy individuals. Selected studies were assessed for methodological quality and data pooled and meta-analysed. Publication bias was tested using Funnel plots. Twelve studies were included in the review (study sample sizes 30-244 participants). Seven of nine studies found statistically significant differences in pain sensitivity response between old (mean ± SD 62.2 ± 3.4 to 79 ± 4 years) and younger adults (22 ± 1.5 to 39.1 ± 8.8 years), but the direction of change was inconsistent. Meta-analysis found that pressure pain threshold was lower in old adults compared with younger adults (p = 0.018, I2  = 60.970%). There were no differences in contact heat pain thresholds between old and younger adults (p = 0.0001, I2  = 90.23%). Three studies found that younger children (6-8.12 years) were more sensitive to noxious stimuli than older children (9-14 years). Methodological quality of studies was high, with a low risk of publication bias. There was substantial statistical and methodological heterogeneity. There is tentative evidence that pressure pain threshold was lower in old adults compared with younger adults, with no differences in heat pain thresholds. Further studies are needed. SIGNIFICANCE: There is tentative evidence that old adults may be more sensitive to mechanically-evoked pain but not heat-evoked pain than young adults. There is a need for further studies on age-related changes in pain perception.

Perceived parenting and psychological well-being in UK ethnic minority adolescents.

BACKGROUND: Warm, caring parenting with appropriate supervision and control is considered to contribute to the best mental health outcomes for young people. The extent to which this view on 'optimal' parenting and health applies across ethnicities, warrants further attention. We examined associations between perceived parental care and parental control and psychological well-being among ethnically diverse UK adolescents. METHODS: In 2003 a sample of 4349 pupils aged 11-13 years completed eight self-reported parenting items. These items were used to derive the parental care and control scores. Higher score represents greater care and control, respectively. Psychological well-being was based on total psychological difficulties score from Goodman's Strengths and Difficulties Questionnaire, increasing score corresponding to increasing difficulties. RESULTS: All minority pupils had lower mean care and higher mean control scores compared with Whites. In models stratified by ethnicity, increasing parental care was associated with lower psychological difficulties score (better mental health) and increasing parental control with higher psychological difficulties score within each ethnic group, compared with reference categories. The difference in psychological difficulties between the highest and lowest tertiles of parental care, adjusted for age, sex, family type and socio-economic circumstances, was: White UK =-2.92 (95% confidence interval -3.72, -2.12); Black Caribbean =-2.08 (-2.94, -1.22); Nigerian/Ghanaian =-2.60 (-3.58, -1.62); Other African =-3.12 (-4.24, -2.01); Indian =-2.77 (-4.09, -1.45); Pakistani/ Bangladeshi =-3.15 (-4.27, -2.03). Between ethnic groups (i.e. in models including ethnicity), relatively better mental health of minority groups compared with Whites was apparent even in categories of low care and low autonomy. Adjusting for parenting scores, however, did not fully account for the protective effect of minority ethnicity. CONCLUSIONS: Perceived quality of parenting is a correlate of psychological difficulties score for all ethnic groups despite differences in reporting. It is therefore likely that programmes supporting parenting will be effective regardless of ethnicity.

Dietary assessment in early old age: experience from the Boyd Orr cohort.

BACKGROUND: The assessment of the impact of data quality issues, such as omitting to answer questions on a food frequency questionnaire (FFQ), is important in all study populations, including those in early old age. Assumptions about the limited nature of diets of older participants may influence the treatment and interpretation of their dietary data. SUBJECTS/METHODS: The Boyd Orr cohort is a long-term study based on 4999 UK men and women whose families took part in a survey of diet and health during 1937-1939. In 1997-1998, all 3182 traced, surviving study members, then aged 60 years and over, were sent a health and lifestyle questionnaire, including a 113-item FFQ, primarily to examine relationships between childhood and adult fruit, vegetable and antioxidant intakes. In-depth interviews were conducted with a purposively sampled subset of 31 respondents. RESULTS: Of the 1475 subjects who returned the questionnaire, 11% (n=161) had missing data on their FFQ. Those who omitted answers to more than 10 questions (n=127; 8.6%) were more likely to be aged over 70, to be female, but no more likely to report being overweight than those with 10 or fewer missing answers. Follow-up by telephone or post to reassess missing FFQ data was successful for 102 of the subjects with more than 10 omitted answers. Mean intakes of energy, fruit and vegetables, and selected nutrients were significantly increased after reassessment. The use of 'cross-check' questions to weigh fruit and vegetable intake (n=1383) showed potentially systematic errors in the reporting of these foods, vitamin C and carotene. Analysis of interview data among a subset of participants partially challenged stereotypical views of the diets of older people with, for example, increased freedom in food choice associated with life transitions. CONCLUSIONS: Food frequency questionnaires for those in early old age, as for others, need to meet competing demands of being comprehensive for those with varied diets, while not being so onerous that they deter completion. Reviewing questionnaires with participants remains important in this group, as omitting to answer questions on the FFQ does not necessarily equate to non-consumption. Qualitative interviews may aid in the interpretation of the quantitative data obtained.

Overweight, obesity and high blood pressure in an ethnically diverse sample of adolescents in Britain: the Medical Research Council DASH study.

OBJECTIVES: To examine the impact of overweight on mean, high normal and high blood pressure in early adolescence, and how this relates to ethnicity and socio-economic status. DESIGN: Cross-sectional study with anthropometric and blood pressure measurements. SETTING: A total of 51 secondary schools in London. SAMPLE: A total of 6407 subjects, 11-13 years of age, including 1204 White UK, 698 Other Whites, 911 Black Caribbeans, 1065 black Africans, 477 Indians and 611 Pakistanis/Bangladeshis. MAIN OUTCOME MEASURES: Mean, high normal (gender, age and height-percentile-specific 90-94th percentile) and high (>/=95th percentile) blood pressure. RESULTS: Based on the International Obesity Task Force age-specific thresholds, 19% of boys and 23% of girls were overweight, and 8% of each were obese. Overweight and obesity were associated with large increases in the prevalence of high normal and high blood pressures compared with those not overweight. The increases in the prevalence of high systolic pressure associated with overweight were as follows: boys, odds ratio 2.50 (95% confidence intervals 1.73-3.60) and girls 3.39 (2.36-4.85). Corresponding figures for obesity were: boys 4.31 (2.82-6.61) and girls 5.68 (3.61-8.95). Compared with their White British peers, obesity was associated with larger effects on blood pressure measures only among Indians, despite more overweight and obesity among black Caribbean girls and overweight among Black African girls. The effect of socio-economic status was inconsistent. CONCLUSIONS: The tendency to high blood pressure among adult Black African origin populations was not evident at these ages. These results suggest that the rise in obesity in adolescence portends a rise in early onset of cardiovascular disease across ethnic groups, with Indians appearing to be more vulnerable.

The popliteofibular ligament. Rediscovery of a key element in posterolateral stability.

We have recently become aware of a strong direct attachment of the popliteal tendon to the fibula. To investigate the importance of this attachment, we examined 20 cadaveric knees. The popliteofibular ligament was identified in all 20 knees. The cross-sectional area of the popliteofibular ligament was 6.9 +/- 2.1 mm2, compared with 7.2 +/- 2.7 mm2 for the lateral collateral ligament. Biomechanical testing of these structures, simulating a purely varus stress on the knee, revealed that the lateral collateral ligament always failed first, followed by the popliteofibular ligament, and then the muscle belly of the popliteus. The mean maximal force to failure of the popliteofibular ligament approached 425 N (range, 204 to 778), compared with 750 N (range, 317 to 1203) for the lateral collateral ligament. Our results indicate that the popliteofibular ligament contributes to posterolateral stability.

The role of the popliteofibular ligament in stability of the human knee. A biomechanical study.

The popliteal tendon has a significant attachment to the fibula, the popliteofibular ligament. The role of this ligament in knee stability has not been determined. In this study we used selective cutting techniques to measure the static contribution of the popliteal tendon attachments to the tibia and the popliteofibular ligament for stability of the knee. Sectioning of all the posterolateral structures except the popliteal tendon attachments to the tibia or the popliteofibular ligament resulted in increased primary posterior translation, varus rotation, external rotation, and coupled external rotation. Although statistically significant, these increases were small. Sectioning of all the posterolateral structures resulted in larger increases in primary posterior translation, varus rotation, external rotation, and coupled external rotation. Our data indicate that the popliteal tendon attachments to the tibia and the popliteofibular ligament are important in resisting posterior translation and varus and external rotation. If an isolated injury to the posterolateral structures occurs, anatomic reconstruction of the major ligaments that restrain posterior translation and varus and external rotation may provide the best functional result. Reconstruction for isolated posterolateral instability should include anatomic attachment of the popliteal tendon to the tibia and the popliteofibular ligament.

Changes in circulatory indices of thrombosis and fibrinolysis during total knee arthroplasty performed under tourniquet.

Deep vein thrombosis may begin during surgery with the tourniquet inflated. Arterial levels of fibrinopeptide A, thrombin-antithrombin complexes, D-dimer, tissue plasminogen activator (t-PA) activity, and t-PA antigen were measured before surgery, during surgery with the tourniquet inflated, and following deflation of the tourniquet in 12 patients undergoing total knee arthroplasty. Minimal increases in fibrinopeptide A, thrombin-antithrombin complexes, and D-dimer were noted during surgery with the tourniquet inflated, but significant increases occurred immediately following deflation of the tourniquet. In 10 patients, intravenous heparin administration significantly suppressed the rise in fibrinopeptide A, but did not significantly alter the increases in either thrombin-antithrombin complexes, D-dimer, t-PA antigen, or t-PA activity. This study provides further evidence that deep vein thrombosis begins during surgery.

The role of the cruciate and posterolateral ligaments in stability of the knee. A biomechanical study.

The role of the posterolateral and cruciate ligaments in restraining knee motion was studied in 11 human cadaveric knees. The posterolateral ligaments sectioned included the lateral collateral and arcuate ligaments, the popliteofibular ligament, and the popliteal tendon attachment to the tibia. Combined sectioning of the anterior cruciate and posterolateral ligaments resulted in maximal increases in primary anterior and posterior translations at 30 degrees of knee flexion. Primary varus, primary internal, and coupled external rotation also increased and were maximal at 30 degrees of knee flexion. Combined sectioning of the posterior cruciate and posterolateral ligaments resulted in increased primary posterior translation, primary varus and external rotation, and coupled external rotation at all angles of knee flexion. Examination of the knee at 30 degrees and 90 degrees of knee flexion can discriminate between combined posterior cruciate ligament and posterolateral injury and isolated posterolateral injury. The standard external rotation test performed at 30 degrees of knee flexion may not be routinely reliable for detecting combined anterior cruciate and posterolateral ligament injury. However, measurements of primary anterior-posterior translation, primary varus rotation, and coupled external rotation may be used to detect combined anterior cruciate and posterolateral ligament injury.

Total hip replacement arthroplasty in patients with inflammatory arthritis.

1. Hip involvement in inflammatory arthritis is a relatively common entity. 2. Total hip replacement offers the most reliable surgical treatment option for pain relief and the restoration of hip function when medical management is exhausted. 3. Preoperative evaluation and perioperative medical management should focus on the particular medical problems of patients with systemic rheumatologic conditions. 4. In patients without protrusio deformity, cemented total hip replacement with modern cement technique offers excellent long-term functional results.

Long-term results of the total condylar knee arthroplasty. A 15-year survivorship study.

This study reports the 15-year survivorship of 112 consecutive Total Condylar knee arthroplasties that have been followed since 1974. Two endpoints were chosen for survivorship: (1) Revision attributable to septic or aseptic loosening or malalignment. (2) Revision or roentgenographic evidence of component loosening. Life table analysis reveals a 94.1% clinical survivorship at 15 years, with an 90.9% survivorship when roentgenographic failures are included. There were five revisions: one for infection, one for instability, and three for tibial loosening. In addition, two tibiae and one patella were considered roentgenographically loose, but were not symptomatic. As of May 1992, 34 patients with 48 knees are known deceased, 15 knees are lost to follow-up evaluation, and 49 knees are available for clinical evaluation. Follow-up data was available on 62 knees for greater than 11 years. Ninety-two percent had good or excellent results, with 1.6% fair and 6.5% poor. Average range of motion was 99 degrees. The average Hospital for Special Surgery knee score was 85. Roentgenographic study revealed lucencies around 72% of tibiae, but only two components were loose. There was a correlation between body weight and the presence of radiolucencies, and patients who weighed more than 80 kg had the lowest survivorship at 15 years: 89.2% clinical survival and 70.6% clinical plus roentgenographic survival. Total Condylar knee arthroplasty has a 94.6% clinical survival at 15 years, with predictably good clinical results.

Neuropathic foot ulceration in patients with myelodysplasia.

To determine if a significant relationship existed between type of operation and eventual development of pedal skin breakdown in a spina bifida patient population, 72 feet in 36 ambulatory patients with low lumbar or sacral myelomeningocele were followed for an average of 14 years 5 months. Using a clinical classification for foot suppleness and position, we determined that foot rigidity, nonplantigrade position, and performance of surgical arthrodesis were clinical indicators that had a strong statistical relationship with eventual development of neuropathic skin changes.

Progression and regression of deep vein thrombosis after total knee arthroplasty.

In this study, patients indicated for primary total knee arthroplasty were prospectively evaluated with serial ascending venography in the index extremities to elucidate the incidence, timing, and evidence of propagation or diminution of any associated deep vein thrombosis. One of 30 limbs evaluated with preoperative venography was positive. Seventy-six knees in 59 patients were evaluated with early and late postoperative venograms. Overall, 47% of limbs were positive at early venography and 54% were positive at late venography. Comparison of early and late results revealed that, in the unilateral arthroplasty group, 86% of eventually positive limbs were already positive within one day after surgery. In the bilateral arthroplasty group, 85% of eventually positive limbs and 87% of eventually positive patients were already positive within one day after surgery. Five percent of unilateral arthroplasty patients and 12% of knees in bilateral arthroplasty patients demonstrated thrombosis proximal to the deep veins of the calf at the early venogram. Late venography demonstrated thrombus formation proximal to the deep veins of the calf in 12% of knees in the unilateral and bilateral groups. No limbs with thrombi less than 9 cm in length at early venography demonstrated thrombosis in or proximal to the popliteal vein at late venography. All thromboses demonstrating propagation into or above the popliteal vein between the early and late venograms did so despite warfarin therapy that had been initiated at the time of the initial positive venogram.

Effect of hypotensive epidural anaesthesia on acetabular cement-bone fixation in total hip arthroplasty.

We selected 20 matched pairs of patients who had had total hip arthroplasty by the same surgeon using the same cemented technique. Matching was by age, sex, height, weight and diagnosis. One of each pair had received hypotensive epidural anaesthesia, with less than 300 ml blood loss: the other had normotensive general anaesthesia with more than 500 ml of blood loss. Early postoperative radiographs were evaluated independently by three blinded observers, using a scoring criteria which assessed the quality of the cement-bone interface. The results showed that patients who had received epidural anaesthesia had significantly better radiographic scores (p less than 0.02). Our findings suggest that hypotensive anaesthesia facilitates penetration of cement into bone.