Does tranexamic acid reliably reduce blood loss in proximal femur fracture surgery?

PURPOSE: The aim of our study was to investigate the use of tranexamic acid in patients with proximal femoral fractures and compare the total blood loss, transfusion rates, complications, and the application method. METHODS: A retrospective single center cohort study (level I trauma center) with 1479 patients treated operatively for a proximal femoral fracture between January 2016 and June 2020 was performed. 1 g of tranexamic acid was applied (systemic, topic or combined application). Patient data, surgical procedure, complications, and mortality were assessed. Hemoglobin levels, blood loss and transfusion rates for patients with and without tranexamic acid and the application methods were compared. RESULTS: 667 femoral neck fractures, 701 pertrochanteric and 109 subtrochanteric fractures were included. Mean age was 80.8 years. 274 patients received tranexamic acid. At admission average hemoglobin was 12.2 g/l. Hemoglobin drop postoperatively was less after tranexamic acid (9.72 vs. 9.35 g/dl). Transfusion rates were lowered significantly by 17.1% after tranexamic acid. Blood loss was reduced for all patients after tranexamic acid independent of fracture morphology. The combination of 1 g i.v. and 1 g topical-applied tranexamic acid seems to be more effective. Complication rates did not differ. CONCLUSION: Tranexamic acid is effective in reducing blood loss and transfusion rates, without increasing the risk of thromboembolic events after proximal femoral fractures. For open reduction and nailing and arthroplasty in fracture setting combined topical and single i.v. application seems most effective and closed reduction with nailing can be treated by single dose i.v. application of 1 g tranexamic acid.

Do patients need advice and information to prevent infections - results of a single centre structured survey.

Background: Healthcare-associated infections are a major burden for hospitals, leading to morbidity and mortality and unnecessary medical costs. They can probably be reduced through what is known as patient empowerment. This study aims to address the question of whether patients are interested in receiving infection prevention and control information. Methods: Patients were asked in structured interviews whether they would like more information on infection prevention and control. Inclusion criteria comprised 2 groups of patients. Group 1 were patients undergoing elective total endoprosthesis (TEP) and Group 2 were patients tested positive for meticillin-resistant Staphylococcus aureus (MRSA). Results: The response rate was 38.4 % (163/425 patients). Approximately 75 % of the patients were interested in information on infection prevention and control. The topics of interest differed between the two patient groups: MRSA patients had a higher need for infection prevention and control information. TEP patients showed a high acceptance of antiseptic body wash and a willingness to pay for it themselves. Information given to patients should be group-specific and timely. Conclusion: Our data suggest a lack of information on infection prevention and control among patients and underline the importance of patient empowerment. The willingness of patients to pay personally for antiseptic wash should be assessed further.

[Intraosseous foreign body or osteoma : Challenging differential diagnosis after open radius fracture]. / Intraossärer Fremdkörper oder Osteom : Anspruchsvolle Differenzialdiagnose nach offener Radiusfraktur.

Presentation of a 16-year-old male patient due to a cycling accident while mountain biking 14 days after primary treatment after open epiphyseal injury. Metaphyseal intraosseous stones within the anatomically reduced distal radius fracture were misinterpreted as an incidental osteoma.

[Compromising due to additive cerclages : Can surgical treatment of humeral shaft fractures cause damage to the radial nerve?] / Kompromittierung durch additive Cerclagen : Ist der N. radialis in der operativen Versorgung der Humerusschaftfraktur in Gefahr?

BACKGROUND: In many cases the treatment of humeral shaft fractures is challenging and despite the large diversity of available approaches, no standard treatment exists. In addition to conservative treatment, intramedullary nails and plate osteosynthesis are competing methods for healing humeral shaft fractures. Furthermore, cerclage is considered to be an additive treatment for spiral fractures; however, this also increases the risk of radial nerve neuropathy and is said to compromise the perfusion of bone fragments. The goal of this study was to investigate secondary radial nerve neuropathy using additive and limited invasive cerclages for nail osteosynthesis of humeral shaft fractures. METHODS: In the present study a total of 102 patients with humeral shaft fractures were clinically and neurologically re-examined after having been treated with nail osteosynthesis and additive cerclage via a limited invasive access over the past 5 years. In total 193 cerclages with limited invasive access were inserted during this time period. RESULTS AND CONCLUSION: Of the patients four (3.9%) showed a secondary radial neuropathy during operative stabilization. Neurophysiological and neurosonographic examinations revealed that this had not been caused by compromising, embedding or severance of the radial nerve due to the cerclage. Two out of these nerve lesions recovered spontaneously within 3 and 6 months, respectively. The other two cases could not be documented over a period of 12 months due to death of the patient. With 3.9% of iatrogenic radial nerve lesions the rate of nerve lesions falls into the lower range of that which has previously been described in the literature for nerve lesions due to operative treatment of humeral shaft fractures (3-12%). We thus conclude that there is no increased risk for iatrogenic injury of the radial nerve using additive and limited invasive cerclage.

[Acute appendicitis after bone grafting from the right anterior iliac crest-difficult differential diagnosis]. / Akute Appendizitis nach Knochenentnahme am rechten Beckenkamm ­ erschwerte Differenzialdiagnostik.

To fill bony defects, an iliac crest bone graft is often used. Typical complications are hematoma, nerve injuries, infection or donor site related pain. This article reports the case of a young patient with acute appendicitis after bone grafting from the right iliac crest. Because of the preceding operation, the correct diagnosis was difficult and was only possible by a differentiated clinical examination followed by machine-aided diagnosis.

[Three-point buttressing with internal fixator for minimally invasive stabilization of the anterior pelvic ring : Operative technique and first clinical results]. / Die Dreipunktabstützung mittels Fixateur interne zur minimalinvasiven Stabilisierung des vorderen Beckenrings : Operative Technik und erste klinische Ergebnisse.

BACKGROUND: The changing age distribution in society inevitably leads to a percentage increase in osteoporotic and fatigue fractures as well as the absolute number of insufficiency fractures of the pelvic ring. Due to pain these fractures lead to a loss of mobility and autonomy. To prevent these consequences surgical treatment is increasingly being performed. OBJECTIVE: This article presents a new configuration of an internal fixator on the anterior pelvic ring, the principle of which correlates to a three-point buttressing. METHODS: In addition to a description of the configuration of the internal fixator on the anterior pelvic ring and the surgical technique, the article presents the results after the first 23 applications. RESULTS: The first results after application of the new internal fixator on the pelvic ring show a low risk, sufficient and minimally invasive stabilization with an encouraging clinical and radiological outcome. CONCLUSION: Missing long-term results, also taking into account a higher number of patients, as well as the biomechanical examination of the presented fixator configuration still have to be evaluated.

[Locked retrograde fibula nail for the surgical treatment of unstable ankle fractures]. / Retrograder Fibulaverriegelungsnagel zur Behandlung von Sprunggelenkfrakturen.

OBJECTIVE: Minimally invasive surgical stabilization of ankle fractures allowing postoperative full weight bearing. INDICATIONS: Unstable ankle fractures type Weber B and C in the geriatric patients or with a critical soft tissue situation. CONTRAINDICATIONS: Ankle fractures in young patients and patients with high demands (relative contraindication). SURGICAL TECHNIQUE: Closed reduction, retrograde insertion of the intramedullary nail into the fibula via a small incision, insertion of up to four locking screws using an aiming device and small incisions. POSTOPERATIVE MANAGEMENT: Full weight bearing in an ankle joint orthosis. RESULTS: In 34 patients who were treated with a retrograde fibula nail, a 6-month follow-up was possible in 18 patients. Osseous consolidation was achieved without any soft tissue complications or infections in all 18 cases. The patients regained their preoperative level of mobility (Parker Mobility Score 4.2 preoperative vs 4.3 postoperative).

[Effectiveness and Cost-Effectiveness of Daily School Sport in the Primary School--Project: "fit for pisa"]. / Effektivität und Kosteneffektivität täglichen Schulsports in der Grundschule--das Projekt "fit für pisa".

The "fit for pisa" intervention implemented daily physical education at five primary schools in Göttingen. The results of the evaluation show an increase in physical activity among the students participating in the programme. At the same time sedentary behaviour, like watching television, decreased remarkably. In the long run the promotion of an active lifestyle had improved the body mass index. The study emphasises the need for government funding to implement the programme across the country.

Mini-midvastus total knee arthroplasty does not result in superior gait pattern.

PURPOSE: Previous studies dealing with gait after minimally invasive surgery (MIS) total knee arthroplasty (TKA) are rare and insufficient. It was the purpose of the study to determine in a prospective, comparative setting whether MIS influences the outcome of TKA in terms of typical 3D gait parameters. METHODS: Patients scheduled for TKA or MIS TKA were invited to participate. MIS TKA was defined as TKA with shorter skin incision, mini-midvastus arthrotomy, special instruments, and avoidance of tibiofemoral dislocation and patella eversion. All other intra- and perioperative aspects were identical for both groups. A 3D gait analysis was performed with a VICON system 1 month preoperative and 8 weeks post-operative. A multivariate analysis of variance was conducted including the main effects time (pre- and post-surgery) and surgical group and the group-by-time interaction effect. RESULTS: Seventeen MIS TKA patients and 20 TKA patients were eligible for the final analysis. We determined neither inter-group differences nor time × group interactions for any gait variables (temporospatial, ground reaction forces, joint angles and joint moments)­except for the varus-valgus knee kinematics. In pre- to post-operative comparison, the maximum valgus sway increased in the MIS group, whereas it decreased in the conventional group (p = 0.001). CONCLUSION: From our findings, it was concluded that MIS TKA does not result in a superior walking pattern 8 weeks post-operative. Because we previously also observed mini-midvastus MIS TKA to have equal or slightly inferior results with regard to knee scores, knee torque, radiographic outcome and tourniquet/operating time, we discontinued the procedure. LEVEL OF EVIDENCE: Prospective comparative study, Therapy, Level II.

Transmission of shiga toxin-producing Escherichia coli O104:H4 at a family party possibly due to contamination by a food handler, Germany 2011.

We investigated a cluster of shiga toxin-producing Escherichia coli (STEC) O104:H4 infections after a family party during a large STEC O104:H4 outbreak in Germany. To identify the vehicle we conducted a retrospective cohort study. Stool samples of party guests, and food and environmental samples from the catering company were tested for STEC. We defined cases as party guests with gastrointestinal symptoms and laboratory-confirmed STEC infection. We found 23 cases among 71 guests. By multivariable analysis consumption of salmon [odds ratio (OR) 15, 95% confidence interval (CI) 2.3-97], herb cream (OR 6.5, 95% CI 1.3-33) and bean salad (OR 6.1, 95% CI 1.4-26) were associated with STEC infection. STEC O104:H4 was detected in samples of bell pepper and salmon. The food handler developed STEC infection. Our results point towards transmission via several food items contaminated by a food handler. We recommend regular education of food handlers emphasizing their role in transmitting infectious diseases.

Ultrasonographic assessment of the spleen in 60 healthy sheep.

AIM: To evaluate the sonographic appearance, size, location and shape of the spleen in 60 healthy sheep. METHODS: A 7.5 MHz linear scanner was used to examine the location, extent and appearance of the spleen from the left side of the sheep, in intercostal spaces (ICS) 8-12 and caudal of the last rib. RESULTS: The ultrasonographic appearance of the splenic parenchyma was homogeneous with a thin, smooth echogenic capsule. The spleen could be visualized in intercostal spaces 9-12 in all sheep, in intercostal space 8 in 25/60 sheep (42%) and caudal of the last rib in 24/60 sheep (40%). In intercostal spaces 8-12 and caudal of the last rib the spleen was visible in 16/60 sheep (27 %). The distance from the dorsal margin of the spleen to the spinous processes of the thoracic vertebrae was greatest in the 8th intercostal space: mean 19.32 (SD 2.76) cm and smallest in the 12th intercostal space: mean 6.61 (SD 1.94) cm. The dorsoventral splenic extent was greatest in the 11th intercostal space: mean 13.69 (SD 2.2) cm and smallest in the 8th intercostal space: mean 7.13 (SD 2.5) cm. The thickness of the spleen ranged from 21 (SD 9.0) mm in the 8th intercostal space to 49 (SD 7.0) mm in the 11th intercostal space. The mean vessel diameter was 1.9 (SD 0.7) mm. Spleen size did not correlate with age, body weight, or thoracic and abdominal circumference. CONCLUSIONS: Ultrasonography is a useful, straightforward and non-invasive method for evaluation of the spleen in sheep. CLINICAL RELEVANCE: These findings provide information which can be used as a reference for sonographic spleen examination and diagnosis of splenic lesions in sheep.

[The direct anterior approach to the hip revision]. / Der direkte anteriore Zugang in der Revisionshüftendoprothetik.

OBJECTIVE: The objective of this paper is to describe a minimally invasive approach to revision total hip arthroplasty. INDICATIONS: Indications for revision hip arthroplasty are septic or aseptic loosening of one or both components of a hip arthroplasty. In revisions the direct anterior approach (DAA) allows for a small incision if only the cup has to be revised or in cases of stem revision; the femoral preparation can be performed strictly endofemorally from the proximal direction. The gluteal muscles can be preserved whether the approach is limited to the original interval between the musculus tensor fasciae latae and the rectus, or has to be extended. CONTRAINDICATIONS: If preservation of the gluteal muscles is desired, the DAA and its extension are the method of choice. For endofemoral revision other than detachment of the musculus tensor fasciae latae, hyperextension and adduction of the operated leg are important. If these cannot be achieved, an alternative operative strategy or a different approach should be considered. As this approach allows for extensions proximally and distally along the femur, it competes with lateral approaches to the hip joint and femur, and does not have additional specific contraindications. The availability of specific curved, angulated, or offset instruments is mandatory. SURGICAL TECHNIQUE: The starting point of the incision is found two fingerbreadths lateral and two finger breadths distal to the anterior superior iliac spine. The fascia of the musculus tensor fasciae latae is incised sharply at its midpoint. The interval is prepared strictly subfacially and medially to the musculus tensor fasciae latae to expose the hip joint. POSTOPERATIVE MANAGEMENT: For this approach we don't have any specific recommendations. Postoperative management depends mostly on the extension of the approach and the type of reconstruction performed. If the approach can be limited to the minimally invasive direct anterior portal, reduced muscle damage should result in faster rehabilitation. RESULTS: The retrospective analysis was performed on the data obtained from 48 revision operations with the minimally invasive direct anterior approach to total hip arthroplasty. The median cut-suture time was 108 min (42-282 min); patients spent a median time of 10 days (4-33 days) in the hospital from the day of the operation. The most common revision operations were cup replacement with an augmentation ring (13 out of 48), stem revision (11 out of 48), cup replacement (9 out of 48), H-TEP complete (3 out of 48), removing of ossifications (2 out of 48), cap revision (2 out of 48) and H-TEP removal with insertion of a spacer (2 out of 48). Complications attributed to the procedure were reported in 9 of the 48 cases: 1 wound-healing disorder, 1 late infection, 1 hematoma, 1 deep vein thrombosis, 1 perforation (by the spacer) and 1 ossification. Two patients were diagnosed with trochanteric pain syndrome. In one case an implant loosening was diagnosed 12 months after the revision.

The User Puzzle—Explaining the Interaction with Visual Analytics Systems.

Visual analytics emphasizes the interplay between visualization, analytical procedures performed by computers and human perceptual and cognitive activities. Human reasoning is an important element in this context. There are several theories in psychology and HCI explaining open-ended and exploratory reasoning. Five of these theories (sensemaking theories, gestalt theories, distributed cognition, graph comprehension theories and skill-rule-knowledge models) are described in this paper. We discuss their relevance for visual analytics. In order to do this more systematically, we developed a schema of categories relevant for visual analytics research and evaluation. All these theories have strengths but also weaknesses in explaining interaction with visual analytics systems. A possibility to overcome the weaknesses would be to combine two or more of these theories.

[Causes of failed osteosynthesis of ankle fractures]. / Ursachen der fehlgeschlagenen Osteosynthese am Sprunggelenk.

Ankle fractures are the most common osseous injuries of the lower extremity. In most cases, open reduction and internal fixation is indicated due to fracture dislocation. Operations of the ankle are generally considered classic, standardized, training procedures. An exact reconstruction with correct length and rotation of the joint as well as stabilization of the tibiofibular ligamentous complex is essential. Beside age and gender of the patient, outcome depends on fracture morphology and comorbidities, e. g., osteoporosis, vascular status, neuropathic disorders, and diabetes mellitus. Additional chondral lesions, extensive closed or open soft tissue injuries, and compartment syndrome due to trauma impact can lead to further problems in the postoperative period. Furthermore, iatrogenic complications like fixed malpositions, instabilities, and implant-associated failure of osteosynthesis may also occur. This article illustrates the causes of preventable mistakes and points out options to increase clinical outcome.

Impaction bone grafting: a laboratory comparison of two methods.

In revision total hip replacement, bone loss can be managed by impacting porous bone chips. In order to guarantee sufficient mechanical strength, the bone chips have to be compacted. The aim of this study was to determine in an in vitro simulation whether the use of a pneumatic hammer leads to higher primary stability than manual impaction. Bone mass characteristics were measured by force and distance variation of a penetrating punch, which was lowered into a plastic cup filled with bone chips. From these measurements bulk density, contact stiffness, impaction hardness and penetration resistance were calculated for different durations of impaction. We found that the pneumatic method reached higher values of impaction hardness, contact stiffness and bulk density suggesting an increase in stability of the implant. No significant differences were found between the two different methods concerning the penetration resistance. The pneumatic method might reduce the risk of fracture in vivo, as force peaks are smaller and applied for a shorter period. Results from manual impaction showed higher variability and depend much on the experience of the surgeon. The pneumatic hammer is a suitable tool to standardise the impaction process.

Injury of the right and left inferior epigastric artery during the implantation of a stand-alone ALIF cage through a left retroperitoneal approach: a case report.

Various perioperative vascular complications of anterior lumbar spine procedures have been described in orthopaedic literature. We report the unusual case of a perioperative bleeding from the right and left epigastric inferior artery occurring when using a stand-alone ALIF device (Synfix, Synthes, Oberdorf, Switzerland) at the L5/S1 level through an anterior left retroperitoneal approach. The primary stability of the Synfix is achieved by four divergent screws which are inserted through the anteriorly located plate into the neighbouring vertebral endplates. For the screw insertion the surrounding structures have to be mobilized more extensively than during a "standard" anterior lumbar interbody fusion (ALIF) procedure. The epigastric inferior arteries were embolized by applying polyvinyl alcohol particles and metal coils. The retroperitoneal haematoma caused herniation of the external rectus sheath. Hence revision surgery with removal of the haematoma and resuturing of the rectus sheath were performed. Insertion of divergent screws of the Synfix device may cause severe distension and rupture of the epigastric vessels. This case shows that a lesion of the right epigastric artery may be a hazard even in left retroperitoneal approaches. To the author's knowledge this is the first case describing a lesion of the right epigastric artery during an ALIF procedure through a left retroperitoneal approach.

Migration of hip revision stems into the knee joint: alternative treatment modalities: technical note.

We report two unusual cases of stem penetration of long shaft femoral prosthesis into the knee joint after revision total hip arthroplasty. In both patients, the protruded tip of the stem interfered with the tibial plateau and averted the knee joint from full range of motion. To avoid further extensive surgery, the tips of the femoral stem were excised using a high speed-cutter. Both patients had immediate improvement in range of motion postoperatively, fast and uncomplicated rehabilitation, immediate pain relief, and good radiological results. If this rare complication occurs, we recommend for a primary intervention to cut the tip of the stem because replacement of the prosthesis would be a long lasting and very exhaustive surgery for affected patients.

Informatics and medicine--from molecules to populations.

OBJECTIVES: To clarify challenges and research topics for informatics in health and to describe new approaches for interdisciplinary collaboration and education. METHODS: Research challenges and possible solutions were elaborated by scientists of two universities using an interdisciplinary approach, in a series of meetings over several months. RESULTS AND CONCLUSION: In order to translate scientific results from bench to bedside and further into an evidence-based and efficient health system, intensive collaboration is needed between experts from medicine, biology, informatics, engineering, public health, as well as social and economic sciences. Research challenges can be attributed to four areas: bioinformatics and systems biology, biomedical engineering and informatics, health informatics and individual healthcare, and public health informatics. In order to bridge existing gaps between different disciplines and cultures, we suggest focusing on interdisciplinary education, taking an integrative approach and starting interdisciplinary practice at early stages of education.

Alpine infrastructure in Central Europe: integral evaluation of wastewater treatment systems at mountain refuges.

Planning, construction and operation of onsite wastewater treatment systems at mountain refuges is a challenge. Energy supply, costly transport, limited water resources, unfavourable climate and load variations are only some of the problems that have to be faced. Additionally, legal regulations are different between and even within countries of the Alps. To ensure sustainability, integrated management of the alpine infrastructure management is needed. The energy and water supply and the wastewater and waste disposal systems and the cross-relations between them were analysed for 100 mountain refuges. Wastewater treatment is a main part of the overall 'mountain refuge' system. The data survey and first analyses showed the complex interaction of the wastewater treatment with the other infrastructure. Main criteria for reliable and efficient operation are training, technical support, user friendly control and a relatively simple system set up. Wastewater temperature, alkalinity consumption and high peak loads have to be considered in the planning process. The availability of power in terms of duration and connexion is decisive for the choice of the system. Further, frequency fluctuations may lead to damages to the installed aerators. The type of water source and the type of sanitary equipment influence the wastewater quantity and quality. Biosolids are treated and disposed separately or together with primary or secondary sludge from wastewater treatment dependent on the legal requirements.

First clinical and biomechanical results of the Trochanteric Fixation Nail (TFN).

Conventional osteosynthesis of proximal femur fractures is still affected by serious complication rates between 4-18%, even though advanced implant modifications and surgical techniques are common practice. In terms of increasing age and co-morbidity of patients this complication ratio is expected to increase even further in the immediate future. One major reason for implant failure is the decreasing stability potential of the implant due to a loss in mechanical properties of cancellous bone. Therefore, efforts in new intramedulary techniques specifically focus on the load bearing characteristics of the implant by developing new geometries to improve the implant-tissue interface. This investigation discusses first clinical results of the trochanteric fixation nail TFN (145 patients) and a biomechanical analysis of the blade/femur head interaction under different static loading conditions. The TFN shows promising performance in first clinical results. In the clinical study the overall complication rate was significantly lower compared to other similar osteosynthesis. For the investigation of the biomechanical stability of the helical TFN blade the following experiments were performed: Analysis of the axial load required for insertion of the blade by free rotation; measurement of the corresponding rotation angle for total insertion (32 mm) (n = 8); pull-out forces with suppressed rotation (n = 4); loads for rotational overwinding of the implant in the fully inserted condition (n = 4). All investigations were performed on human femoral heads. The bone mineral densities of the specimens were detected by QCT-scans. Prior to cadaveric testing the experimental set-up was validated (n = 8) by the use of synthetic foam blocks (Sawbone).