ABSTRACT
Current methods for tuberculosis treatment monitoring are suboptimal. We evaluated plasma matrix metalloproteinase (MMP) and procollagen III N-terminal propeptide concentrations before and during tuberculosis treatment as biomarkers. Plasma MMP-1, MMP-8, and MMP-10 concentrations significantly decreased during treatment. Plasma MMP-8 was increased in sputum Mycobacterium tuberculosis culture-positive relative to culture-negative participants, before (median, 4993â pg/mL [interquartile range, 2542-9188] vs 698 [218-4060] pg/mL, respectively; P = .004) and after (3650 [1214-3888] vs 720 [551-1321] pg/mL; P = .008) 6 months of tuberculosis treatment. Consequently, plasma MMP-8 is a potential biomarker to enhance tuberculosis treatment monitoring and screen for possible culture positivity.
Subject(s)
Matrix Metalloproteinase 8 , Tuberculosis, Pulmonary , Biomarkers , Humans , Matrix Metalloproteinase 8/blood , Mycobacterium tuberculosis , Sputum , Tuberculosis, Pulmonary/complications , Tuberculosis, Pulmonary/diagnosisABSTRACT
A two and a half year review of 39 peripartum hysterectomies done at Ga-Rankuwa Hospital from 1 January 1993 to 30 June 1995 was conducted. There were a total of 21,108 deliveries, 4,894 (23.19 pc) of which were caesarean deliveries. The ages of the patients ranged from 17 to 46 years and parity from 0 to 9. A large number, 31 (79.5 pc) of the patients were unbooked. The commonest indications were ruptured uterus 14 (35.9 pc) puerperal sepsis 13 (33.3 pc) and post partum haemorrhage four (10.3 pc). The complications included wound dihescence, sepsis, bladder injury, ureteral injury and two deaths occurred.
