ABSTRACT
We detected and analysed the Gm and Km allotype markers of Ig in 57 patients affected by uveitis, an ocular inflammation with multifactorial etiology. The aim of the present study has been to investigate the possibility that different immunogenetic factors predispose to the various forms of the disease. We found a statistically significant alteration of Km(1) allele frequency (relative risk = 2.65). That seems to predispose to anterior uveitis, especially when associated with a blank at HLA-A locus (RR = 7.83) but predispose to the posterior form when in combination with HLA-B38 (RR = 19.24). Moreover, a high frequency of Km(1)/A blank phenotypic association was noticed in uveitis with infectious aetiology (RR rising to 10.44). The Km(1) genotype may itself predispose to uveitis and its combination with different HLA alleles could enhance the susceptibility to one particular form rather than to another.
Subject(s)
HLA Antigens/genetics , Immunoglobulin Light Chains/genetics , Uveitis/genetics , Adolescent , Adult , Aged , Alleles , Child , Female , Gene Frequency , Genetic Markers , Humans , Immunoglobulin Allotypes/genetics , Immunoglobulin Gm Allotypes/genetics , Male , Middle Aged , Uveitis/immunologyABSTRACT
We have assessed the efficacy of 0.5% piroxicam collyrium applied for 15 days to the eyes of rabbits in which uveitis had been experimentally induced. The results demonstrate the capability of the drug to easily overcome the ocular barrier. On the 30th day, a clear regression of the uveitis symptoms was observed, the hyperaemia having completely disappeared. By means of radioimmunological assay (RIA), it was found that the increased PGF2 alpha concentration in the aqueous humour had returned to normal levels.
Subject(s)
Piroxicam/therapeutic use , Prostaglandins F/biosynthesis , Uveitis/drug therapy , Administration, Topical , Animals , Dinoprost , Male , Piroxicam/administration & dosage , Prostaglandins F/analysis , Rabbits , Radioimmunoassay , Uveitis/metabolismABSTRACT
Eighty-nine unrelated patients with ocular inflammation (uveitis) were investigated for the HLA class I and class II genetic markers, We subdivided our patients according to: 1. the anatomical location of the lesion; 2. the temporal course of the disease; 3. the aetiology. We eliminated from our sample of patients the individuals with other systemic diseases. We could not find an association with B27, as previously described, but we did note statistically significant differences between the class II antigen distribution in the different anatomical subgroups. HLA-DR3 seems a marker of the intermediate form of uveitis (p, uncorrected 0.03); the absence of DR1 in the patient group with posterior uveitis may be a protecting factor (p. uncorrected less than 0.01); the presence of DR4 in all cases of panuveitis is statistically significant (p, uncorrected = 0.0006).
Subject(s)
HLA-D Antigens/analysis , HLA-DQ Antigens/analysis , HLA-DR Antigens/analysis , Uveitis/genetics , Adolescent , Adult , Aged , Child , Disease Susceptibility , Female , Gene Frequency , HLA Antigens/analysis , HLA Antigens/genetics , HLA-DQ Antigens/genetics , HLA-DR Antigens/genetics , Humans , Male , Middle Aged , Uveitis/classificationABSTRACT
Phakomatoses are congenital diseases characterized by several neoformations affecting tissues originated from ectoderm. The most typical ophthalmic affection is the retinal hamartoma: it can be of angiomatous (Von Hippel-Lindau's Syndrome, Sturge-Weber's Disease) or neuroglioblastic type (Von Recklinghausen's Disease, Bourneville's Disease). In addition to the above-mentioned ones, some include among phakomatoses other diseases such as Louis-Bar's Syndrome, Rendu-Osler's Syndrome and, recently, Gorlin-Goltz's Syndrome. Authors present the case of a young girl, who in addition to the typical G-G's Syndrome osteo-cutaneous features was affected by retinal lesions of hamartomatous type. Photographic documents are displayed.